Celine Louapre

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BACKGROUND AND OBJECTIVE Cognitive and behavioural symptoms are common in multiple sclerosis (MS), but they are rarely the inaugural and predominant manifestation of the disease. Our objective is to characterize the clinical and radiological features of cognitive-multiple sclerosis (cog-MS), defined as MS subjects who entered into the disease with cognitive(More)
The exact pathophysiological mechanisms leading to the activation and sensitization of the trigeminovascular pathway, which in turns results in the migraine attack, are not completely elucidated. It is likely that direct activation by cortical spreading depression, together with dysfunctional central control of pain, plays a major role in the onset and(More)
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