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The Peroxisome-Mitochondria Connection: How and Why?
TLDR
A comprehensive look at how peroxisomal and mitochondrial abundance are controlled by common sets of cis- and trans-acting factors and how these organelles cooperate in various metabolic and signaling pathways is provided.
Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts
TLDR
This study shows that PEX5 proteins fused to a bulky C-terminal tag trigger peroxisome degradation in SV40 large T antigen-transformed mouse embryonic fibroblasts and provides evidence that this process is autophagy-dependent and requires monoubiquitination of the N-Terminal cysteine residue that marks P EX5 for recycling.
Peroxisomal Hydrogen Peroxide Metabolism and Signaling in Health and Disease
TLDR
The focus of this review is to comprehensively evaluate the evidence that peroxisomes, organelles best known for their role in cellular lipid metabolism, also serve as hubs in the H2O2 signaling network.
Redox interplay between mitochondria and peroxisomes
TLDR
This review critically review and discusses emerging evidence that peroxisomes and mitochondria share an intricate redox-sensitive relationship and cooperate in cell fate decisions, and highlights the need for more studies that seek to clarify the mechanisms of how mitochondria may act as dynamic receivers, integrators, and transmitters ofperoxisome-derived mediators of oxidative stress.
The peroxisomal protein import machinery displays a preference for monomeric substrates
TLDR
This work shows that PEX5 binds newly synthesized (monomeric) acyl-CoA oxidase 1 (ACOX1) and urate oxidase (UOX), potently inhibiting their oligomerization, and suggests that monomeric ACOX1 and UOX are better peroxisomal import substrates than the corresponding oligomeric forms.
Redox Signaling from and to Peroxisomes: Progress, Challenges, and Prospects.
TLDR
This review introduces the reader to what is known about the role of peroxisomes in cellular H2O2 production and clearance, with a focus on mammalian cells and describes the benefits and drawbacks of current strategies used to investigate the complex interplay betweenperoxisome metabolism and cellular redox state.
Peroxisomes as Modulators of Cellular Protein Thiol Oxidation: A New Model System.
TLDR
The development of a human cell line that can be used to selectively generate H2O2 inside peroxisomes in a time- and dose-controlled manner and the extent of protein oxidation depends on the subcellular location of the target protein and is inversely correlated to catalase activity and cellular glutathione content are reported.
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