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- Keith P. Romano, Akbar Ali, William E. Royer, Celia A Schiffer
- Proceedings of the National Academy of Sciences…
- 2010
Hepatitis C virus infects an estimated 180 million people worldwide, prompting enormous efforts to develop inhibitors targeting the essential NS3/4A protease. Resistance against the most promising… (More)
- Thomas D. Wu, Celia A Schiffer, +7 authors Robert W. Shafer
- Journal of virology
- 2003
Although many human immunodeficiency virus type 1 (HIV-1)-infected persons are treated with multiple protease inhibitors in combination or in succession, mutation patterns of protease isolates from… (More)
- Moses M. Prabu-Jeyabalan, Ellen A. Nalivaika, Celia A Schiffer
- Structure
- 2002
The homodimeric HIV-1 protease is the target of some of the most effective antiviral AIDS therapy, as it facilitates viral maturation by cleaving ten asymmetric and nonhomologous sequences in the Gag… (More)
- Weijun Chen, Suvana S. Lam, +6 authors William E. Royer
- Nature Structural &Molecular Biology
- 2008
Interferon regulatory factors (IRFs) are essential in the innate immune response and other physiological processes. Activation of these proteins in the cytoplasm is triggered by phosphorylation of… (More)
- Walter Robert Peter Scott, Celia A Schiffer
- Structure
- 2000
BACKGROUND
The human immunodeficiency virus type 1 (HIV-1) protease is an essential viral protein that is a major drug target in the fight against Acquired Immune Deficiency Syndrome (AIDS). Access… (More)
- Markus-Frederik Bohn, Shivender M. D. Shandilya, +13 authors Celia A Schiffer
- Structure
- 2013
Human APOBEC3F is an antiretroviral single-strand DNA cytosine deaminase, susceptible to degradation by the HIV-1 protein Vif. In this study the crystal structure of the HIV Vif binding,… (More)
- Shivender M. D. Shandilya, Madhavi N. L. Nalam, +12 authors Celia A Schiffer
- Structure
- 2010
APOBEC3G is a DNA cytidine deaminase that has antiviral activity against HIV-1 and other pathogenic viruses. In this study the crystal structure of the catalytically active C-terminal domain was… (More)
- Nancy M. King, Moses M. Prabu-Jeyabalan, Ellen A. Nalivaika, Piet Tom Bert Paul Wigerinck, Marie-Pierre P de Béthune, Celia A Schiffer
- Journal of virology
- 2004
TMC114, a newly designed human immunodeficiency virus type 1 (HIV-1) protease inhibitor, is extremely potent against both wild-type (wt) and multidrug-resistant (MDR) viruses in vitro as well as in… (More)
- Keith P. Romano, Akbar Ali, +9 authors Celia A Schiffer
- PLoS pathogens
- 2012
Hepatitis C virus (HCV) infects over 170 million people worldwide and is the leading cause of chronic liver diseases, including cirrhosis, liver failure, and liver cancer. Available antiviral… (More)
- Matthieu Foll, Yu-Ping Poh, +15 authors Jeffrey D Jensen
- PLoS genetics
- 2014
The challenge of distinguishing genetic drift from selection remains a central focus of population genetics. Time-sampled data may provide a powerful tool for distinguishing these processes, and we… (More)