Cees A M de Wit

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OBJECTIVE To assess the association between bullying (both directly and indirectly) and indicators of psychosocial health for boys and girls separately. STUDY DESIGN A school-based questionnaire survey of bullying, depression, suicidal ideation, and delinquent behavior. SETTING Primary schools in Amsterdam, The Netherlands. PARTICIPANTS A total of(More)
Levels of blood coagulation factors were measured monthly in hedgehogs kept at 20 degrees C under a natural-light schedule for 1 yr using prothrombin time and the P & P method. Hedgehogs display a circannual cycle of blood coagulation factors in the absence of temperature cues, with high levels corresponding to the active period and low levels corresponding(More)
BACKGROUND AND METHOD The behaviour of 30 depressed 3- to 6-year-olds was observed in three play situations (solitary free play, interactive free play, and play narratives) and compared to the behaviour of 30 nondepressed clinical and 30 nondepressed nonclinical peers. RESULTS Depressed children showed significantly less play, particularly less symbolic(More)
Hedgehog (Erinaceus europaeus) plasma contains factor(s) which neutralize the hemorrhagic activity of European viper (Vipera berus) venom. These antihemorrhagic factor(s) were purified by gel filtration on Sephacryl S-200 and chromatography on Cibacron Blue Sepharose. The macroglobulin fraction obtained was characterized for proteinase inhibiting activity,(More)
Prairie vole (Microtus ochrogaster) serum has no anti-lysing or antibody activity against Osage copperhead (Agkistrodon contortrix phaeogaster) venom. However, the serum has an anti-hemorrhagic component, which significantly reduces the size of hemorrhage produced by the minimal hemorrhagic dose of venom and which blocks the minimal hemorrhagic dose at a(More)
1. Endogenous phospholipase A2 (PLA2) inhibitors in human plasma and in plasma from the hedgehog (Erinaceus europaeus) were demonstrated. 2. The PLA2 activity increased 45-fold in human plasma when a PLA2 binding factor was removed. Furthermore, two peaks of PLA2 inhibitory activity were found after DEAE-chromatography. 3. High levels of PLA2 inhibitory(More)
Three macroglobulin inhibitors were purified from hedgehog (Erinaceus europaeus) plasma by sequential chromatography on Cibacron Blue Sepharose, Sephacryl S-200 and preparative agarose gel electrophoresis. Each macroglobulin was characterized for proteinase inhibiting activity, molecular weight by polyacrylamide gel electrophoresis (PAGE), subunit size by(More)
Hedgehog plasma was separated by gel filtration on Sephacryl S-200, the fractions resolved by electrophoresis and the electrophoretograms characterized for collagenase, papain and plasmin inhibiting activities with the high mol. wt substrate casein. The three inhibitors previously identified as alpha 2-, alpha 2-beta- and beta-macroglobulins were found to(More)
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