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The synthesis and enzyme inhibition data for a series of thiadiazole urea matrix metalloproteinase (MMP) inhibitors are described. A broad screening effort was utilized to identify several… (More)
Protein tyrosine phosphatase 1B (PTP1B) attenuates insulin signaling by catalyzing dephosphorylation of insulin receptors (IR) and is an attractive target of potential new drugs for treating the… (More)
The Contractor's attention is directed to the fact that there are right of way acquisitions that have not been completed. The State anticipates that all remaining right of way acquisitions will be… (More)
Some research centres are more equal than others.