Population Pharmacokinetics of Clozapine and Norclozapine and Switchability Assessment between Brands in Uruguayan Patients with Schizophrenia
- I. Olmos, M. Ibarra, M. Vázquez, Cecilia Maldonado, P. Fagiolino, G. Giachetto
- Medicine, PsychologyBioMed Research International
- 6 March 2019
Evaluated the magnitude and variability of concentration exposure to CZP and its active metabolite NCZP on pharmacokinetic parameters in Uruguayan patients with schizophrenia with a focus on covariates using population PK (PPK) modeling methodologies, hinting a bioequivalence scenario in the clinical setting.
Pain Relief - From Analgesics to Alternative Therapies
- Cecilia Maldonado
- 24 May 2017
Lamotrigine-Valproic Acid Interaction Leading to Stevens–Johnson Syndrome
The case of an 8-year-old boy who suffered from SJS and other complications two weeks after LTG was added to his VPA treatment in order to control his seizures is presented.
Potential therapeutic role of carnitine and acetylcarnitine in neurological disorders.
- Cecilia Maldonado, M. Vázquez, P. Fagiolino
- Medicine, PsychologyCurrent pharmaceutical design
- 11 February 2020
ALCAR emerges as a simple, economical and safe adjuvant option in order to impair the progression of most neurological disorders.
Hyperammonemia Associated with Valproic Acid Concentrations
Extended-release (twice daily) formulations of valproic acid or carnitine supplementation are the proposed two therapeutic strategies in order to reverse hyperammonemia.
Usefulness of salivary drug monitoring for detecting efflux transporter overexpression.
A novel subrogate using two protocolized saliva samples sequentially collected (first, S1, and second, S2) was designed in order to replace V and A free plasma drug concentrations, respectively, showing that S1/S2 saliva drug concentration ratio was sensitive enough for detecting systemic clearance changes.
Pharmacokinetics of Subcutaneous Levetiracetam in Palliative Care Patients.
Evaluating effectiveness and tolerability of SC LEV as well as characterizing its pharmacokinetics found it to be effective and well tolerated in patients with seizures.
Development of a Population Pharmacokinetic Model for Cyclosporine from Therapeutic Drug Monitoring Data
- Martín Umpiérrez, Natalia Guevara, M. Ibarra, P. Fagiolino, M. Vázquez, Cecilia Maldonado
- Medicine, BiologyBioMed Research International
- 8 April 2021
A population pharmacokinetic model was developed to reasonably estimate the individual cyclosporine clearance for patients and can be utilized to individualize CsA doses for prompt and adequate achievement of target blood concentrations of Cs a.
Influence of Efflux Transporters on Drug Metabolism
- P. Fagiolino, M. Vázquez, R. Eiraldi, Cecilia Maldonado, A. Scaramelli
- Biology, MedicineClinical Pharmacokinetics
- 1 February 2011
A multicompartment pharmacokinetic model was developed in order to explain different behaviours of antiepileptic drugs using a single mechanism of inductive action, and the key for solving apparent dissimilarities was to consider in the model the unique physiological connection that intestine, liver and bloodstream have.
Contribution of the Antiepileptic Drug Administration Regime in the Development and/or Establishment of Pharmacoresistant Epilepsy
The present chapter deals with the difficulty anticonvulsant agents have in reaching the brain receptor sites.