Cecilia Gunnarsson

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The 17b-hydroxysteroid dehydrogenase (17HSD) enzymes are involved in the local regulation of sex steroids. The 17HSD type 1 enzyme catalyses the interconversion of the weak oestrone (E1) to the more potent oestradiol (E2), whereas 17HSD type 2 catalyses the oxidation of E2 to E1. The aim of this study was to correlate the expression of these enzymes in the(More)
BACKGROUND Ring chromosome 10 is a rare cytogenetic finding. Of the less than 10 reported cases we have found in the literature, none was characterized using high-resolution microarray analysis. Ring chromosomes are frequently unstable due to sister chromatid exchanges and mitotic failures. When mosaicism is present, the interpretation of genotype-phenotype(More)
Cell fusion is a natural process in normal development and tissue regeneration. Fusion between cancer cells and macrophages generates metastatic hybrids with genetic and phenotypic characteristics from both maternal cells. However, there are no clinical markers for detecting cell fusion in clinical context. Macrophage-specific antigen CD163 expression in(More)
Gravitational lensing of high-redshift supernovae is potentially an important source of uncertainty when deriving cosmological parameters from the measured brightness of Type Ia supernovae, especially in deep surveys with scarce statistics. Photometric and spectroscopic measurements of foreground galaxies along the lines-of-sight of 33 supernovae discovered(More)
The human epidermal growth factor receptor 2 gene (HER2) is amplified in approximately 15%–20% of all breast cancers. This results in overexpression of the HER2 protein, which is associated with worse clinical outcomes in breast cancer patients. Several studies have shown that trastuzumab, a monoclonal antibody that interferes with the HER2/neu receptor,(More)
INTRODUCTION 17β-Hydroxysteroid dehydrogenases (17βHSDs) are important enzymes regulating the pool of bioactive steroids in the breast. The current study was undertaken in order to evaluate implications of 17βHSD14 in breast cancer, measuring 17βHSD14 protein expression in breast tumours. METHODS An antibody targeting the 17βHSD14 antigen was generated(More)
Stål and Agneta Jansson, 17β-hydroxysteroid dehydrogenase type 14 is a predictive marker for tamoxifen response in oestrogen receptor positive breast cancer, 2012, PLoS ONE, (7), 7, e40568. Abstract Introduction: 17b-hydroxysteroid dehydrogenases (17bHSDs) are important enzymes regulating the pool of bioactive steroids in the breast. The current study was(More)
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