Cecilia Cristea

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During the last decades the incidence of cancer increased dramatically especially in developed countries. In spite of the fact that the immunochemical methods allowed the diagnosis in early stages, the biopsies are generally invasive methods that create discomfort to patients. The need for fast, sensitive, easy to use and noninvasive diagnosis tools is(More)
A simple and highly sensitive approach for the detection of the anti-neoplastic drug gemcitabine is presented, based on a one-step electropolymerized molecularly imprinted microporous-metal-organic-framework. The sensitive layer was prepared by electropolymerization of the aniline moieties of p-aminothiophenol- gold nanoparticles on the surface of gold(More)
The development of composite electrodes for biosensors construction based on HRP and zirconium alcoxide film for acetaminophen detection and finally, acetaminophen determination in pharmaceutical products is described. The enzyme immobilization is performed by retention in a polyetilenimine and zirconium alcoxide porous gel film, technique that offers a(More)
Due to the rapidity and the effectiveness of the method, the reduction of diazonium salts has been widely used to functionalize electrodes for sensor applications. However, the resulting organic film usually designed to provide complexing capabilities for the species to be determined could affect the sensor properties. The electrochemical reduction of(More)
Metamizol, a pyrazolone derivative, is commonly implicated in IgE-mediated allergic reactions. Skin tests have different sensitivity in drug allergy diagnosis and false positive or false negative results render their interpretation difficult, especially because the ranges of the tested concentrations have not been adequately investigated in all drugs. The(More)
The detection of biological molecules referred as biomarkers in biological fluids is fundamental in clinical analysis because it permits to discriminate between healthy and ill individuals and to evaluate the progress of a disease. The ability to identify a disease at an early stage and/or with high precision is a primary element of successful therapeutic(More)
In this work, we report the design, the development and the characterization of the analytical performances of a colorimetric smartphone-based immunosensor for the detection of cancer antigen 125 (CA125). The immunosensor was based on a sandwich strategy in which the primary antibody was immobilized by spotting onto the 3D nitrocellulose membrane. The(More)
Advances in nanoscience have allowed scientists to incorporate new nanomaterials in biosensing platforms. Carbon nanotubes are nanomaterials that facilitate the charge transfer between the bioelement and the transducer. Electrochemical impedance spectroscopy is a useful technique for the modified surface characterization. In the present approach(More)
The electrochemical behavior of ascorbic acid and uric acid on glassy carbon bare electrodes and ones modified with β-cyclodextrin entrapped in polyethyleneimine film has been investigated using square wave voltammetry. The electrode modification was achieved in order to separate the voltammetric peaks of ascorbic acid and uric acid when present in the same(More)
The design and development of an electrochemical sensor for the sensitive and selective determination of pyoverdine, a virulence factor secreted by Pseudomonas aeruginosa, bacteria involved in nosocomial infections is presented in this work. The presence of pyoverdine in water and body fluids samples can be directly linked to the presence of the Pseudomonas(More)