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Of the several families of adhesion receptors involved in leukocyte-endothelial cell interactions, only the selectins have been shown to initiate leukocyte interaction under physiologic shear; indeed, beta 2 (CD18) intergrins responsible for neutrophil arrest are unable to engage without prior selectin-mediated rolling. In contrast, alpha 4 (CD49d)(More)
The L-selectin, a cell surface C-type lectin, directs lymphocyte traffic to lymph nodes, and contributes to lymphocyte homing to Peyer's patches and to leukocyte interactions with inflamed venules. Here we report that the mucosal vascular addressin MAdCAM-1, a mucosal endothelial adhesion molecule with immunoglobulin- and mucin-like domains, is a(More)
The mucosal vascular addressin, MAdCAM-1, is an immunoglobulin superfamily adhesion molecule for lymphocytes that is expressed by mucosal venules and helps direct lymphocyte traffic into Peyer's patches (PP) and the intestinal lamina propria. We demonstrate that the lymphocyte integrin alpha 4 beta 7, also implicated in homing to PP, is a receptor for(More)
Production development can conflict with production ergonomics and management of environmental impacts. In this paper, we describe how ergonomics can be assessed in production system design by means of a joint simulation tool. The tool enables ergonomics and environmental impacts assessment in conjunction with production process development. The ergonomics(More)
In industrial production companies, the practice of assigning responsibility for human factors and ergonomics (HFE) to specific professionals (referred to as HF agents in this paper) may take on various organizational forms. This interview study examines the extent to which HF agents are able to give input towards the design of new production systems in(More)