Cecilia A. Hale

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BACKGROUND Calcium absorption is generally considered to be impaired under conditions of vitamin D deficiency, but the vitamin D status that fully normalizes absorption is not known for humans. OBJECTIVE To quantify calcium absorption at two levels of vitamin D repletion, using pharmacokinetic methods and commercially marketed calcium supplements. (More)
BACKGROUND Lifestyle measures are considered the first line of therapy for treating overweight individuals, but many are unable to achieve a meaningful weight loss. OBJECTIVE To determine the efficacy and safety of orlistat 60 mg, given 3 times daily, for weight loss in mildly to moderately overweight individuals. METHODS A multicenter, 16 week,(More)
BACKGROUND Cost-effectiveness of calcium supplementation depends not only on the cost of the product but on the efficiency of its absorption. Published cost-benefit analyses assume equal bioavailability for all calcium sources. Some published studies have suggested that there are differences in both the bioavailability and cost of the major calcium(More)
OBJECTIVE The study was conducted to provide information on how consumers would use orlistat 60 mg, especially in terms of product dosing, in a setting without physician supervision. METHODS AND PROCEDURES A 3-month, open-label, naturalistic study was conducted in an over-the-counter (OTC) setting in 18 pharmacies. Consumers >/=18 years were allowed to(More)
A picture-naming task was used to examine word-finding problems in language-impaired children. The subjects included 20 language-impaired children, 20 normal children matched to the language-impaired children for chronological age, and 20 normal children matched to the language-impaired children on a composite index of language age. Children were shown 64(More)
In a novel use of electronic documents to replace labor-intensive programming, a SAS-based integration has been implemented that uses XML to automate the creation, revision, and reuse of the publication-quality statistical tables prominent in regulatory submissions. Table content and style revision is XML document-based, not programming-based. The XML(More)
Statisticians often spend more time programming and supervising the programming for tables than they spend on the statistical analyses reported in the tables. Features new in versions 7 and 8 of SAS coupled with XML make it possible to reduce this programming load by automating analysis steps. In the automated system, a statistician prepares table shells(More)
Cornfield's test-based method of setting a confidence interval on a parameter associated with a two-by-two contingency table is adapted for use with the measure of agreement kappa. One-sided confidence intervals derived in this way are compared to other intervals proposed for kappa under two study designs. Both designs involve two ratings per subject on a(More)
SAS sometimes provides an optimal environment for part of an assignment but third-party applications provide a better environment for other parts. The creation of report-quality statistical tables is such a situation. SAS is optimal for statistics but clumsy for publishing report-quality tables. XML offers a new way to integrate SAS with publishing(More)
Analysts attracted to SAS for its statistical capabilities no longer have to settle for its clumsy publishing capabilities. Instead, they can take advantage of the Output Delivery System (ODS) in version 7.0, SAS’s data warehouse and data processing capabilities, and a new open-source, non-proprietary software technology, and literally never use a DATA(More)