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The Aurora kinases are essential for the regulation of chromosome segregation and cytokinesis during mitosis. Aberrant expression and activity of these kinases occur in a wide range of human tumors, and lead to aneuploidy and tumorigenesis. Here we report the discovery of a highly potent and selective small-molecule inhibitor of Aurora kinases, VX-680, that(More)
Acute myeloid leukemias (AML) with myelodysplasia-related changes (AML-MRC) are defined by the presence of multilineage dysplasia (MLD), and/or myelodysplastic syndrome (MDS)-related cytogenetics, and/or previous MDS. The goal of this study was to identify distinct biological and prognostic subgroups based on mutations of ASXL1, RUNX1, DNMT3A, NPM1, FLT3(More)
activation by daunorubicin mediated Raf-1/extracellular-regulated kinase ζ Protein kinase C (1930 articles) Signal Transduction (4217 articles) Neoplasia Articles on similar topics can be found in the following Blood collections Information about subscriptions and ASH membership may be found online at: articles must include the digital object identifier(More)
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