Cecelia A. Shertz

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BACKGROUND The nutrient-sensing Tor pathway governs cell growth and is conserved in nearly all eukaryotic organisms from unicellular yeasts to multicellular organisms, including humans. Tor is the target of the immunosuppressive drug rapamycin, which in complex with the prolyl isomerase FKBP12 inhibits Tor functions. Rapamycin is a gold standard drug for(More)
In eukaryotes from yeast to humans, the Tor signaling cascade responds to nutrients and growth factors to orchestrate cell growth and proliferation. The central elements of this signaling cascade are the Tor protein kinases, which are the targets of the potent anti-proliferative and immunosuppressive natural product rapa-mycin [1]. Most organisms, including(More)
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