Cathy Mathis

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PURPOSE The prevalence of bladder dysfunctions increases with age. In humans it is difficult to separate changes related to exogenous factors from those directly related to the aging process. Some confounding variables can be avoided by studying age related changes in an animal model. We evaluated the impact of age on bladder function in vivo and in vitro,(More)
There has been increasing interest in the potential use of erythromycin as a prokinetic agent, despite limited data on the effect of oral administration on gastrointestinal motility. We have now evaluated, in 15 conscious pigs fitted with strain gauges, the response of (i) basal gastric motility and (ii) gastric motility during inhibition with intraduodenal(More)
BACKGROUND/AIMS The proximal stomach is considered as the main contributor to liquid emptying. The aim of this study was to investigate the capacity of the distal stomach to generate transpyloric flow pulses in the absence of the proximal stomach. METHODS Concurrent motility and flow measurements were made in eight anesthetized pigs. Four animals had the(More)
Pyloric resistance is probably a major factor regulating gastric emptying of liquids, but its nervous control is unknown. The role of efferent vagal pathways in pyloric resistance was evaluated in 13 anesthetized pigs. Pyloric resistance was assessed by simultaneous recording of gastropyloroduodenal motility and transpyloric flow during gastric emptying of(More)
Gastric emptying is usually measured in animals and humans by dilution/sampling or external scintigraphy. These methods are either time consuming or require expensive equipment. The capacity of a miniature gamma counter positioned in the stomach to measure emptying of liquid and solid meals was evaluated. In eight conscious pigs fitted with gastric and(More)
Erythromycin increases gastric emptying but the characteristics of transpyloric flow and the contribution of pyloric resistance to the mechanisms of increased flow are unknown. Transpyloric outflow and gastroduodenal pressures were studied in eight anaesthetized pigs during intravenous infusion of erythromycin (10 mg kg-1). Erythromycin increased emptying(More)
Erythromycin overcomes postvagotomy gastroparesia in patients without a distal stomach and functional pylorus. We investigate the role of the vagus in gastric emptying increased by erythromycin, using a model that preserves the physiology of the distal stomach and pylorus. The effects of erythromycin lactobionate (10 mg/kg) on transpyloric flow pattern and(More)
The effects of small intestinal infusion of nutrients on the transpyloric flow and pyloric resistance were evaluated in anaesthetized pigs. Saline versus isocaloric solutions of dextrose, triglycerides and casein were infused into a jejunal loop during saline gastric loading. Antropyloroduodenal pressures were measured with a sleeve/side-hole manometric(More)