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OBJECTIVE Despite increased risk, most offspring of parents with bipolar disorder (BP) do not manifest BP. The identification of risk factors for BP among offspring could improve preventive and treatment strategies. We examined this topic in the Pittsburgh Bipolar Offspring Study (BIOS). METHOD Subjects included 388 offspring, ages 7-17 years, of 233(More)
OBJECTIVES To assess aggression, irritability and hostility in children at risk for bipolar disorder (BP). METHODS Using the parent and the child versions of the Children's Hostility Inventory (CHI), we assessed aggression, hostility, and irritability in 300 offspring aged 6-18 years old of BP parents and 169 children of community controls. RESULTS(More)
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