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Rearrangements of MLL (encoding lysine-specific methyltransferase 2A and officially known as KMT2A; herein referred to as MLL to denote the gene associated with mixed-lineage leukemia) generate MLL fusion proteins that bind DNA and drive leukemogenic gene expression. This gene expression program is dependent on the disruptor of telomeric silencing 1-like(More)
MLL-rearrangements generate MLL-fusion proteins that bind DNA and drive leukemogenic gene expression. This gene expression program is dependent on the histone 3 lysine 79 (H3K79) methyltransferase DOT1L, and small molecule DOT1L inhibitors show promise as therapeutics for these leukemias. However, the mechanisms underlying this dependency are unclear. We(More)
A block design D = (V, B) is a set V of v elements together with a set B of b subsets of V called blocks, each containing exactly k elements, such that each element of V occurs in precisely r blocks, for some positive integers rand k. D is called a t-design if every t-subset of V occurs in exactly At blocks, for some positive integer At. Such a design D is(More)
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