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- Stephan Ripke, Colm Ó'Dúshláine, +164 authors Patrick F. Sullivan
- Nature Genetics
- 2013
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia… (More)
- Paul R. Burton, David G. Clayton, +209 authors Mathew Brown
- Nature Genetics
- 2007
We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis (AS), autoimmune thyroid disease… (More)
- Emma Hockly, Victoria M. Richon, +13 authors Gillian P Bates
- Proceedings of the National Academy of Sciences…
- 2003
Huntington's disease (HD) is an inherited, progressive neurological disorder that is caused by a CAG/polyglutamine repeat expansion and for which there is no effective therapy. Recent evidence… (More)
- Stephan Ripke, Naomi R Wray, +113 authors Patrick F. Sullivan
- Molecular Psychiatry
- 2013
Prior genome-wide association studies (GWAS) of major depressive disorder (MDD) have met with limited success. We sought to increase statistical power to detect disease loci by conducting a GWAS… (More)
- Sang Hong Lee, Stephan Ripke, +367 authors Naomi R Wray
- Nature Genetics
- 2013
Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic… (More)
- M. B. A. Parkes, Jeffrey C. Barrett, +28 authors Christopher G Mathew
- Nature Genetics
- 2007
A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other… (More)
- Cathryn M. Lewis, Douglas F. Levinson, +50 authors Tómas Helgason
- American journal of human genetics
- 2003
Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to siblings of probands. Replication has been inconsistent for reports of significant genetic linkage. To… (More)
- Jack Euesden, Cathryn M. Lewis, Paul F. O'Reilly
- Bioinformatics
- 2015
SUMMARY
A polygenic risk score (PRS) is a sum of trait-associated alleles across many genetic loci, typically weighted by effect sizes estimated from a genome-wide association study. The application… (More)
- Rudolf Uher, Patricia Huezo-Diaz, +23 authors Ian W. Craig
- The Pharmacogenomics Journal
- 2009
The objective of the Genome-based Therapeutic Drugs for Depression study is to investigate the function of variations in genes encoding key proteins in serotonin, norepinephrine, neurotrophic and… (More)
Genome scan meta-analysis of schizophrenia and bipolar disorder, part I: Methods and power analysis.
- Douglas F. Levinson, Matthew D Levinson, Ricardo Segurado, Cathryn M. Lewis
- American journal of human genetics
- 2003
This is the first of three articles on a meta-analysis of genome scans of schizophrenia (SCZ) and bipolar disorder (BPD) that uses the rank-based genome scan meta-analysis (GSMA) method. Here we used… (More)