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- Paul R. Burton, David G. Clayton, +212 authors Mathew Brown
- Nature Genetics
- 2007
We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis (AS), autoimmune thyroid disease… (More)
- Emma Hockly, Victoria M. Richon, +13 authors Gillian P Bates
- Proceedings of the National Academy of Sciences…
- 2003
Huntington's disease (HD) is an inherited, progressive neurological disorder that is caused by a CAG/polyglutamine repeat expansion and for which there is no effective therapy. Recent evidence… (More)
- Sang Hong Lee, Stephan Ripke, +367 authors Naomi R Wray
- Nature Genetics
- 2013
Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic… (More)
- Stephan Ripke, Naomi R Wray, +113 authors Patrick F. Sullivan
- Molecular Psychiatry
- 2013
Prior genome-wide association studies (GWAS) of major depressive disorder (MDD) have met with limited success. We sought to increase statistical power to detect disease loci by conducting a GWAS… (More)
- M. B. A. Parkes, Jeffrey C. Barrett, +28 authors Christopher G Mathew
- Nature Genetics
- 2007
A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other… (More)
- Cathryn M. Lewis, Douglas F. Levinson, +50 authors Tómas Helgason
- American journal of human genetics
- 2003
Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to siblings of probands. Replication has been inconsistent for reports of significant genetic linkage. To… (More)
- Lesley H Wise, Jerry S. S. Lanchbury, Cathryn M. Lewis
- Annals of human genetics
- 1999
We have developed a method for meta-analysis of genome scans which allows systematic integration of data from published results. The Genome Search Meta-analysis method (GSMA) uses a non-parametric… (More)
- Andrew P. Cuthbert, Sheila A. Fisher, +10 authors Christopher G Mathew
- Gastroenterology
- 2002
BACKGROUND & AIMS
Mutations in the NOD2 gene are strongly associated with susceptibility to Crohn's disease (CD). We analyzed a large cohort of European patients with inflammatory bowel disease to… (More)
- Douglas F. Levinson, Matthew D Levinson, Ricardo Segurado, Cathryn M. Lewis
- American journal of human genetics
- 2003
This is the first of three articles on a meta-analysis of genome scans of schizophrenia (SCZ) and bipolar disorder (BPD) that uses the rank-based genome scan meta-analysis (GSMA) method. Here we used… (More)
- Emma Hockly, Benjamin Woodman, Amarbirpal Mahal, Cathryn M. Lewis, Gillian P Bates
- Brain research bulletin
- 2003
The R6/2 mouse is the most widely used animal model of Huntington's disease (HD), a genetic disorder causing movement disorders, personality changes, dementia, and premature death, for which there is… (More)