Catherine P A O'Sullivan

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BACKGROUND/AIMS Abnormal cerebral metabolism and cognitive impairments have been reported in patients with chronic hepatitis C (HCV) but studies have failed to demonstrate a relationship between these findings. METHODS Twenty-five HCV-positive patients with histologically-mild liver disease were studied with cerebral proton magnetic resonance spectroscopy(More)
Sphingosine 1-phosphate (S1P) receptors (S1PRs) belong to the class A family of G protein-coupled receptors (GPCRs). S1PRs are widely expressed on many cell types, including those of the immune, cardiovascular, and central nervous systems. The S1PR family is rapidly gaining attention as an important mediator of many cellular processes, including cell(More)
Globoid cell leukodystrophy (Krabbe disease) is a rare infantile neurodegenerative disorder. Krabbe disease is caused by deficiency in the lysosomal enzyme galactocerebrosidase (GALC) resulting in accumulation, in the micromolar range, of the toxic metabolite galactosylsphingosine (psychosine) in the brain. Here we find that psychosine induces human(More)
OBJECTIVES to evaluate specialist geriatric input and medication review in patients in high-dependency continuing care. DESIGN prospective, randomised, controlled trial. SETTING two residential continuing care hospitals. PARTICIPANTS two hundred and twenty-five permanent patients. INTERVENTION patients were randomised to either specialist geriatric(More)
A direct capture enzyme-linked immunosorbent assay (ELISA) was developed to measure elevated polymorphonuclear granulocyte (PMN) antigens using horseradish peroxidase (EC conjugated rabbit polyclonal anti-PMN antisera and a monoclonal antibody specific for PMN cells. Optical densities obtained in the ELISA were used to predict the cell counts of(More)
The activities of mitochondrial complex III (ubiquinol-cytochrome c reductase, EC and complex IV (cytochrome c oxidase EC are reduced by 30-70% in Huntington's disease and Alzheimer's disease, respectively, and are associated with excitotoxic cell death in these disorders. In this study, we investigated the control that complexes III and(More)
PURPOSE To investigate variation in pH generated by different analysis techniques and to find the most robust method, 31P MR brain spectra were acquired in vivo. Three different methods were used to measure the chemical shift of inorganic phosphate (Pi) relative to phosphocreatine (PCr). MATERIALS AND METHODS Eight healthy volunteers were scanned four(More)
The influence of various factors on the concentrations of polymorphonuclear neutrophilic leukocytes (PMN) in milk samples from bulk tanks and individual cows was investigated. While somatic cell counts (SCC) and PMN level were in both cases significantly correlated, lower correlation coefficients were found between SCC and PMN for samples of bulk tank milks(More)
Neuropathic pain can arise from lesions to peripheral or central nerve fibres leading to spontaneous action potential generation and a lowering of the nociceptive threshold. Clinically, neuropathic pain can manifest in many chronic disease states such as cancer, diabetes or multiple sclerosis (MS). The bioactive lipid, lysophosphatidic acid (LPA), via(More)
The peak and critical state strengths of sands are linearly related to the stress level, just as the frictional resistance to sliding along an interface is related to the normal force. The analogy with frictional sliding has led to the use of a 'friction angle' to describe the relationship between strength and stress for soils. The term 'friction angle'(More)