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INTRODUCTION The management of malignant pleural mesothelioma represents one of the most challenging issues in oncology, as there is no proven long-term benefit from surgery, radiotherapy or chemotherapy alone or in combination. Locoregional progression remains the major cause of death, but radical surgical resection may produce major postoperative… (More)
This article traces the history of two clinical cases. The first case describes a substance abusing patient who enacted the part of a narcotics addict. This enactment was affirmed by both alcohol and narcotic treatment programs, leading to a misdiagnosis. The second case describes a substance using client misdiagnosed as a result of assumptions made by the… (More)
INTRODUCTION To investigate anatomical response-related changes in the head and neck region during a course of radical radiotherapy and their impact on the planned dosimetry. METHODS The study consisted of 10 patients with primary mucosal carcinoma. Patients' nutritional requirements were managed as per departmental protocol to minimise weight loss during… (More)
Measurements of peak flow, vital capacity, FEV1 and flow volume studies were performed in healthy volunteers for 20 weeks following intranasal vaccination with live-attenuated A/Victoria/3/75 recombinants or placebo. Despite differing attenuation of the two candidate strains, no effect on pulmonary function was detected.
Intensity-modulated radiotherapy (IMRT) has reduced the impact of acute and late toxicities associated with head and neck radiotherapy. Treatment planning system (TPS) advances in biological cost function based optimization (BBO) and improved segmentation techniques have increased organ at risk (OAR) sparing compared to conventional dose-based optimization… (More)