Catherine Helmer

Pascale Barberger-Gateau8
Claudine Berr6
8Pascale Barberger-Gateau
6Claudine Berr
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Better knowledge of the preclinical phase of Alzheimer's disease would be an important advance to allow earlier treatment of this ominous disease. This prodromal period was investigated in the Paquid cohort by analysing change in cognitive performances at five time points over a 9 year period. Neuropsychological measures including global cognitive(More)
The influence of education, occupation, and leisure activities on the passive and active components of reserve capacity remains unclear. We used the voxel-based morphometry (VBM) technique in a population-based sample of 331 nondemented people in order to investigate the relationship between these factors and the cerebral volume (a marker of brain reserve).(More)
  • Luc Letenneur, Karine Pérès, Hervé Fleury, Isabelle Garrigue, Pascale Barberger-Gateau, Catherine Helmer +3 others
  • 2008
BACKGROUND Herpes Simplex Virus (HSV) infection has been proposed as a possible risk factor of Alzheimer's Disease (AD) notably because it is neurotropic, ubiquitous in the general population and able to establish lifelong latency in the host. The fact that HSV was present in elderly subjects with AD suggests that the virus could be a co-factor of the(More)
Between 100 and 150 words attester 1. INTRODUCTION Exploration of video surveillance material for the purposes of healthcare and home assistance to elderly population is now becoming in the focus of attention of multidisciplinary research, both medical practitioners and computer scientists. With the ageing of population in the world, the care of dementia(More)
Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of(More)
OBJECTIVE Associations between metabolic syndrome and its individual components with risk of incident dementia and its different subtypes are inconsistent. RESEARCH DESIGN AND METHODS The 7,087 community-dwelling subjects aged > or =65 years were recruited from the French Three-City (3C) cohort. Hazard ratios (over 4 years) of incident dementia and its(More)
We consider the problem of estimating the intensity functions for a continuous time 'illness-death' model with intermittently observed data. In such a case, it may happen that a subject becomes diseased between two visits and dies without being observed. Consequently, there is an uncertainty about the precise number of transitions. Estimating the intensity(More)
OBJECTIVE To examine 1) the associations between history of cardio-cerebrovascular diseases (CVD) and insomnia complaints and excessive daytime sleepiness (EDS), and 2) the relationships between sleep complaints and future CVD in persons over 65. METHODS CVD was assessed at baseline and during two, four, and six-year follow-up in 5494 non-demented(More)
  • Catherine Féart, Catherine Helmer, Hervé Fleury, Yannick Béjot, Karen Ritchie, Philippe Amouyel +5 others
  • 2011
OBJECTIVE Herpes simplex virus (HSV) reactivation has been identified as a possible risk factor for Alzheimer's disease (AD) and plasma amyloid-beta (Aβ) levels might be considered as possible biomarkers of the risk of AD. The aim of our study was to investigate the association between anti-HSV antibodies and plasma Aβ levels. METHODS The study sample(More)
BACKGROUND Numerous studies have looked at the potential benefits of various nootropic drugs such as Ginkgo biloba extract (EGb761®; Tanakan®) and piracetam (Nootropyl®) on age-related cognitive decline often leading to inconclusive results due to small sample sizes or insufficient follow-up duration. The present study assesses the association between(More)