Catherine Grgicak

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There are three dominant contributing factors that distort short tandem repeat profile measurements, two of which, stutter and variations in the allelic peak heights, have been described extensively. Here we characterise the remaining component, baseline noise. A probabilistic characterisation of the non-allelic noise peaks is not only inherently useful for(More)
Biological evidence may contain any number of cells in any proportion. Extreme low-template DNA samples are often very difficult to interpret due to complex signal or peaks which may be indistinguishable from baseline noise. Current solutions focus on increasing the amount of amplicon detected by adjusting PCR cycle number or capillary electrophoresis(More)
When collecting biological evidence from a crime scene, it is important to determine the most effective and robust collection method to ensure maximum DNA recovery. Some common biological collection methods include swabbing, cutting, scraping, and taping. Although these common techniques for biological collection have been a mainstay of forensic analysis,(More)
iii ACKNOWLEDGEMENTS I would like to thank Catherine Grgicak for all of her help throughout this project and writing this thesis. All of the time that she spent troubleshooting with me was invaluable. Her encouragement and willingness to find time in her busy schedule to meet with me so often has helped me enormously throughout my time at Boston University.(More)
iv ACKNOWLEDGEMENTS Catherine, you made it your personal mission to ensure that this thesis was a success. You were willing to take me on as your mentee with a compressed timeline, introduced me to an engaging problem that I enjoyed attacking, and accommodated many post-work conferences. Thank you for helping me finish and for providing me with direction(More)
iii Acknowledgements I would like to express my sincere gratitude to all those individuals who provided me with their reassurance, guidance, and expertise throughout the course of this project. Without their support, this thesis would not have come to fruition. I would specifically like to thank my husband, Stephan, for his endless encouragement; my(More)
iv ACKNOWLEDGEMENTS First and foremost, I would like to thank Dr. Catherine Grgicak for her endless support and guidance during both the research and writing phases of this thesis. Without her dedication and constant willingness to help, none of this work would have been possible. I would also like to extend my gratitude to Ms. Erin Forry and Ms. Amy(More)
The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Abstract—For forensic purposes, short tandem repeat allele signals are used as DNA fingerprints. The interpretation of signals measured from samples has traditionally been conducted by applying thresholding. More quantitative approaches(More)
Many samples submitted for DNA analysis from crime scenes are often degraded or contain DNA mixtures from two or more individuals. Degradation of DNA in these samples presents a challenge as larger molecular weight STR markers are inefficiently amplified, if they are amplified at all, potentially resulting in a significant loss of information. Furthermore,(More)
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