Catherine Emma Jones

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Using a non-invasive MRI technique for measuring the refractive index distribution through the crystalline lens, refractive index maps were obtained through 20 intact isolated human lenses (7-82years). Focal length measurements, obtained by simulated light ray propagation through each index map were found to be in agreement with direct measurements(More)
PURPOSES To determine axial, vertical, and horizontal eye dimensions in myopic and emmetropic eyes by using magnetic resonance imaging (MRI) and to relate these to different ocular expansion models of myopia development. METHODS The internal length (cornea to retina), height and width (both retina to retina) were measured in emmetropic and myopic eyes (up(More)
BACKGROUND Plasma concentrations of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, are raised in patients with chronic vascular disease, causing increased cardiovascular risk and endothelial dysfunction, but the role of ADMA in acute inflammatory states is less well defined. METHODS AND RESULTS In a prospective(More)
PURPOSE To determine and compare the shapes of the retinas of emmetropic and myopic eyes. METHODS Nonrotationally symmetrical ellipsoids were mathematically fitted to the retinal surfaces of 21 emmetropic and 66 myopic eyes (up to -12 D) of participants aged 18 to 36 years (mean, 25.5) using transverse axial and sagittal images derived from magnetic(More)
There is increasing recognition of the clinical importance of endogenous nitric oxide synthase inhibitors in critical illness. This has highlighted the need for an accurate high performance liquid chromatography (HPLC) method for detection of asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) in small volumes of blood. Here, the(More)
Asymmetrical dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), is a predictor of mortality in critical illness. Severe malaria (SM) is associated with decreased NO bioavailability, but the contribution of ADMA to the pathogenesis of impaired NO bioavailability and adverse outcomes in malaria is unknown. In adults with and(More)
We compare the focal lengths of porcine lenses measured optically and by using a novel MRI technique. The geometric properties of the lenses were also measured and compared. The MRI technique exploits the dependence of both the lens refractive index and relaxation rates on the local protein concentration. By measuring the refractive index and corresponding(More)
INTRODUCTION Estrogen depletion after menopause is accompanied by bone loss and architectural deterioration of trabecular bone. The hypothesis underlying this work is that the microMRI-based virtual bone biopsy can capture the temporal changes of scale and topology of the trabecular network and that estrogen supplementation preserves the integrity of the(More)
The human lens comprises two distinct regions in which the refractive index changes at different rates. The periphery contains a rapidly increasing refractive index gradient, which becomes steeper with age. The inner region contains a shallow gradient, which flattens with age, due to formation of a central plateau, of RI = 1.418, which reaches a maximum(More)