Catherine Cho

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The mal de debarquement syndrome (MdDS), a continuous feeling of swaying, rocking, and/or bobbing, generally follows travel on the sea. The associated symptoms cause considerable distress. The underlying neural mechanisms are unknown, and to date there have been no effective treatments for this condition. Results in monkeys and humans suggested that MdDS(More)
Freezing of gait, a paroxysmal motor block, is common in the latter stages of Parkinson's disease. The current 'gold standard' of assessing the severity of freezing is based on clinical identification (by up to 3 raters) of the number of episodes from video. The aims of this study were to systematically assess this 'gold standard' across multiple(More)
BACKGROUND Mutations in LYST, a gene encoding a putative lysosomal trafficking protein, cause Chédiak-Higashi syndrome (CHS), an autosomal recessive disorder typically characterized by infantile-onset hemophagocytic syndrome and immunodeficiency, and oculocutaneous albinism. A small number of reports of rare, attenuated forms of CHS exist, with affected(More)
BACKGROUND Status dystonicus (SD) is a rare and potentially life-threatening complication of primary or secondary dystonia, characterized by acute worsening of dystonic movements. There is no consensus regarding optimal treatment, which may be medical and/or surgical. METHODS We present our experience with pallidal deep brain stimulation (DBS) in 5(More)
Gait dysfunction and falling are major sources of disability for patients with advanced Parkinson's disease (PD). It is presently thought that the fundamental defect is an inability to generate normal stride length. Our data suggest, however, that the basic problem in PD gait is an impaired ability to match step frequency to walking velocity. In this study,(More)
The current 'gold standard' for clinical evaluation of freezing of gait (FOG) in Parkinson's disease (PD) is determination of the number of FOG episodes from video by independent raters. We have previously described a robust technique for objective FOG assessment from lower-limb acceleration. However, there is no existing method for validation of autonomous(More)
Gait and balance disturbances are amongst the most disabling features of Parkinson's disease (PD), and are not adequately controlled with currently available medical and surgical therapies. Development of objective quantitative measures of these abnormalities would greatly help in the assessment and the development of therapeutic interventions. Recently, we(More)
1 PARKINSONIAN GAIT 2 3 4 5 6 7 Catherine Cho, Mikhail Kunin, Koji Kudo, Yasuhiro Osaki, C Warren Olanow, 8 Bernard Cohen, and Theodore Raphan 2, 1 9 10 11 12 13 14 From the Dept. of Neurology, Mount Sinai School of Medicine, New York, New York, 15 10029, USA, Dept. of Computer and Information Science, City University of New York 16 (Brooklyn College and(More)