Catherine Cheung

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The Werner and Bloom syndromes are caused by loss-of-function mutations in WRN and BLM, respectively, which encode the RecQ family DNA helicases WRN and BLM, respectively. Persons with Werner syndrome displays premature aging of the skin, vasculature, reproductive system, and bone, and those with Bloom syndrome display more limited features of aging,(More)
The approach to acute cognitive dysfunction varies among physicians, including intensivists. Physicians may differ in their labeling of cognitive abnormalities in critically ill patients. We aimed to survey: (a) what Canadian intensive care unit (ICU) physicians identify as “delirium”; (b) choices of non-pharmacological and pharmacological management; and(More)
Chronic lymphocytic leukemia (CLL) is predominantly a disease of accumulation rather than rapid proliferation. To date, no cell lines exist, as CLL cells undergo rapid apoptosis when cultured in vitro, suggesting that a favorable in vivo microenvironment is required. To identify survival signals we cultured primary CLL peripheral blood mononuclear cells(More)
Traumatic brain injury (TBI) is a leading cause of sustained impairment in military and civilian populations. However, mild (and some moderate) TBI can be difficult to diagnose because the injuries are often not detectable on conventional MRI or CT. Injured brain tissues in TBI patients generate abnormal low-frequency magnetic activity (ALFMA, peaked at 1-4(More)
Human arylamine N-acetyltransferases (NAT) bioactivate arylamine and heterocyclic amine carcinogens present in red meat and tobacco products. As a result, factors that regulate expression of NATs have the potential to modulate cancer risk in individuals exposed to these classes of carcinogens. Because epidemiologic studies have implicated well-done meat(More)
The recent literature has addressed many ®nancial and managerial aspects of downsizing, end-user computing, outsourcing, re-engineering, and CASE-based applications development. In contrast, little is known about how the IS community perceives and is affected by these emerging practices. A recent study examined the perceptions and attitudes of IS(More)
With more than 5.5 million fractures and 1 million bone repair surgeries annually, bone graft plays a significant role in aiding fracture repair. In the United States alone, surgeons perform an estimated 500,000 to 600,000 bone grafting procedures annually. With the advent of possibilities from bone substitutes, growth factors, and stem cell research, the(More)
A series of thirteen patients that had primary fusion of the ankle joint through an isolated medial approach is presented. The technique involves transection of the medial malleolus for access to the articular surfaces, rather than the traditional transfibular approach. The medial malleolus was replaced in all cases, preserving the deltoid ligament. Union(More)
To show the efficacy of an allogenic bone graft in elective foot surgery, the authors report on 39 consecutive procedures in which allograft was implanted in 26 patients during a 30-month period. These procedures were performed for a variety of conditions, including arthrodesis, segmental lengthening, and treatment of nonunion. Allograft material consisted(More)
BACKGROUND A 75-year-old man on methotrexate immunosuppression for myasthenia gravis presented with a 2-month history of lymphocytosis and bilateral inguinal adenopathy. There were no constitutional symptoms of fever, night sweats, or weight loss. INVESTIGATIONS Physical examination, blood tests, flow cytometry, fluorescent in situ hybridization,(More)