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OBJECTIVE The amplitude-modulation-following response (AMFR) is the frequency component detectable in the electroencephalogram (EEG) or magnetoencephalography (MEG) corresponding to the modulation frequency of an amplitude modulated tone used as a continuous acoustic stimulus. Various properties of the AMFR depend on modulation frequency, suggesting that(More)
PURPOSE To compare the diagnostic results of four perimetric tests and to identify useful parameters from each for determining abnormality. METHODS One hundred eleven eyes with glaucomatous optic neuropathy (GON), 31 with progressive optic neuropathy (PGON) 53 with ocular hypertension, and 51 with no disease were included (N = 246). Visual field results(More)
PURPOSE To determine whether a variational Bayesian independent component analysis mixture model (vB-ICA-mm), a form of unsupervised machine learning, can be used to identify and quantify areas of progression in standard automated perimetry fields. METHODS In an earlier study, it was shown that a model using vB-ICA-mm can separate normal fields from(More)
PURPOSE To determine the relationship between areas of glaucomatous retinal nerve fiber layer thinning identified by optical coherence tomography and areas of decreased visual field sensitivity identified by standard automated perimetry in glaucomatous eyes. DESIGN Retrospective observational case series. PARTICIPANTS Forty-three patients with(More)
PURPOSE To compare the ability of several machine learning classifiers to predict development of abnormal fields at follow-up in ocular hypertensive (OHT) eyes that had normal visual fields in baseline examination. METHODS The visual fields of 114 eyes of 114 patients with OHT with four or more visual field tests with standard automated perimetry over(More)
PURPOSE To assess the agreement of disc topography measurements between the Heidelberg Retina Tomograph (HRT II), Retinal Thickness Analyzer (RTA), and Optical Coherence Tomograph (StratusOCT). DESIGN Observational cross-sectional study. PARTICIPANTS Forty-two randomly chosen eyes of 42 subjects. METHODS Each subject underwent HRT II, RTA, and(More)
PURPOSE To determine whether an unsupervised machine learning classifier can identify patterns of visual field loss in standard visual fields consistent with typical patterns learned by decades of human experience. METHODS Standard perimetry thresholds for 52 locations plus age from one eye of each of 156 patients with glaucomatous optic neuropathy (GON)(More)
PURPOSE To evaluate the accuracy of a prototype electronic device for recording eye drop usage. PARTICIPANTS AND METHODS Ten volunteers were randomly assigned to one of five usage patterns designed to mimic common patterns of use in glaucoma patients from 100% compliant to 50% compliant. All participants agreed to adhere to a pre-determined "dosing"(More)
PURPOSE To determine typical patterns of repeatable glaucomatous visual field progression. DESIGN Retrospective analysis of data obtained from two prospective studies. METHODS Included were 72 eyes of 72 patients tested up to six times over 2 years, and 40 eyes of 40 patients followed annually for up to 12 years. Each patient had two abnormal baseline(More)
OBJECTIVE To investigate differences in visual function between the healthy eyes of people of African (AD) and European descent (ED). METHODS Visual function was assessed in 393 AD and 367 ED participants selected from the African Descent and Glaucoma Evaluation Study and the Diagnostic Innovations in Glaucoma Study. Participants had normal appearance of(More)