Catherine A. Thornton

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BACKGROUND Health is a result of influences operating at multiple levels. For example, inadequate housing, poor educational attainment, and reduced access to health care are clustered together, and are all associated with reduced health. Policies which try to change individual people's behaviour have limited effect when people have little control over their(More)
BACKGROUND The vulnerability of clinical trials to volunteer bias is under-reported. Volunteer bias is systematic error due to differences between those who choose to participate in studies and those who do not. METHODS AND RESULTS This paper extends the applications of the concept of volunteer bias by using data from a trial of probiotic supplementation(More)
OBJECTIVE To evaluate a multistrain, high-dose probiotic in the prevention of eczema. DESIGN A randomised, double-blind, placebo-controlled, parallel group trial. SETTINGS Antenatal clinics, research clinic, children at home. PATIENTS Pregnant women and their infants. INTERVENTIONS Women from 36 weeks gestation and their infants to age 6 months(More)
The use of manual microscopy for the scoring of chromosome damage in the in vitro micronucleus assay is often associated with user subjectivity. This level of subjectivity can be reduced by using automated platforms, which have added value of faster with high-throughput and multi-endpoint capabilities. However, there is a need to assess the reproducibility(More)
Implantable ventricular assist devices (VADs) have proven efficient in advanced heart failure patients as a bridge-to-transplant or destination therapy. However, VAD usage often leads to infection, bleeding, and thrombosis, side effects attributable to the damage to blood cells and plasma proteins. Measuring hemolysis alone does not provide sufficient(More)
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