The epidermal growth factor receptor (EGFR) is implicated in breast cancer (BC) progression and is associated with an aggressive phenotype. The presence of EGFR mutations in exons 18–21 in BC, as in non-small-cell lung cancer , might help predict patient response to EGFR inhibitors such as erlotinib and gefitinib. The EGFR mutation rate in patients with… (More)
BACKGROUND Youths in sub-Saharan Africa (SSA) account for a large burden of the global HIV/STI crises. As such, strategies directed at promoting behavioral modifications would be critical to reducing the prevalence of risky sexual behaviors among high risk adolescents in post-conflict environments. OBJECTIVES This study describes a condom promotion… (More)
Key components to support local institutional and consumer markets are: supply chain, finance, clinical use, and consumer use. Key lessons learned: (1) Build supply and demand simultaneously. (2) Support a lead organization to drive the introduction process. (3) Plan for scale up from the start. (4) Profitability for the private sector is an absolute.