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Circadian Regulation of Gene Expression Systems in the Drosophila Head
Mechanisms composing Drosophila's clock are conserved within the animal kingdom. To learn how such clocks influence behavioral and physiological rhythms, we determined the complement of circadianExpand
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A yeast-endonuclease-generated DNA break induces antigenic switching in Trypanosoma brucei
Trypanosoma brucei is the causative agent of African sleeping sickness in humans and one of the causes of nagana in cattle. This protozoan parasite evades the host immune system by antigenicExpand
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Integration of Light and Temperature in the Regulation of Circadian Gene Expression in Drosophila
Circadian clocks are aligned to the environment via synchronizing signals, or Zeitgebers, such as daily light and temperature cycles, food availability, and social behavior. In this study, we foundExpand
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Control of Daily Transcript Oscillations in Drosophila by Light and the Circadian Clock
The transcriptional circuits of circadian clocks control physiological and behavioral rhythms. Light may affect such overt rhythms in two ways: (1) by entraining the clock circuits and (2) viaExpand
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An endonuclease-generated DNA break induces antigenic switching in Trypanosoma brucei
Trypanosoma brucei is the causative agent of African sleeping sickness in humans and one of the causes of nagana in cattle. This protozoan parasite evades the host immune system by antigenicExpand
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Telomere Length Affects the Frequency and Mechanism of Antigenic Variation in Trypanosoma brucei
Trypanosoma brucei is a master of antigenic variation and immune response evasion. Utilizing a genomic repertoire of more than 1000 Variant Surface Glycoprotein-encoding genes (VSGs), T. brucei canExpand
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Strategies to construct null and conditional null Trypanosoma brucei mutants using Cre-recombinase and loxP.
We describe two gene-knockout (KO) strategies in Trypanosoma brucei using Cre recombinase and loxP sites. Due to the limited number of selection markers for T. brucei, it has been difficult toExpand
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period and timeless mRNA Splicing Profiles under Natural Conditions in Drosophila melanogaster
Previous analysis of Drosophila circadian behavior under natural conditions has revealed a number of novel and unexpected features. Here we focus on the oscillations of per and tim mRNAs and theirExpand
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Long-term time estimation is influenced by circadian phase
The adaptive significance of a putative time sense in humans remains unclear as do the factors that underlie the capacity to gauge the passage of time. Here we show that the subjective assessment ofExpand
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The In(put)s and Out(put)s of the Drosophila Circadian Clock
Circadian clocks are aligned to the 24‐h environmental day via zeitgebers, and information from the clock must be relayed to the rest of the organism. Recent studies addressing temperature as anExpand
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