Catharina Riedemann

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OBJECTIVE To investigate whether typical neuropathological and radiological findings can be identified in patients with the clinical diagnosis of the Heidenhain variant of Creutzfeldt-Jakob disease (CJD). DESIGN Case study. The clinical symptoms, neuropathological findings, electroencephalograms, magnetic resonance images, and cerebrospinal fluid samples(More)
OBJECTIVE To report the clinical and pathologic features of patients with the D178N-129M mutation living in Germany. METHODS Patients with clinically suspected Creutzfeldt-Jakob disease (CJD) were seen in an ongoing, prospective epidemiologic study from June 1993 to August 1997 throughout Germany. Suspect patients were referred to the CJD unit by the(More)
The discovery of services that are appropriate for answering a given question is a crucial task in the open and distributed environment of web services for geographic information. In order to find these services the concepts underlying their implementation have to be matched against the requirements resulting from the question. It is in this matchmaking(More)
Creutzfeldt-Jakob disease (CJD) is a rare neurodegenerative human disorder with an incidence of one case per 1000000 per year. Recently new diagnostic tests such as neuron-specific enolase (NSE), S-100, tau-protein and protein 14-3-3 have been established as markers in prion diseases. NSE is elevated in case of rapid nerve cell loss so quantitative(More)
OBJECTIVES Among the classification criteria for the diagnosis of Creutzfeldt-Jakob disease, akinetic mutism is described as a symptom which helps to establish the diagnosis as possible or probable. Akinetic mutism has been anatomically divided into two forms--the mesencephalic form and the frontal form. The aim of this study was to delimit the symptom of(More)
Usage modeling seeks to provide end users with a usable - that is, effective, efficient, and satisfactory - interactive product. In a usage-centered development process, users must understand what they need to perform their work tasks. Various techniques exist for collecting and documenting what is understood about the user and future system usage. From the(More)
The fact that many decisions need a combination of information sources makes easy integration of geospatial data an important data usability issue. Our vision is to achieve automated just-in-time integration. As a foundation, we present a system architecture with distributed data and services. Existing and evolving standards and technologies fitting into(More)
User interfaces of geospatial information systems (GIS) are endowed with natural language terms describing topological operators in spatial queries. Thus, users do not have to learn underlying models and their formal languages in order to communicate with the system. Nevertheless, we have observed difficulties with identifying the appropriate operator for a(More)