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Neuronal nicotinic acetylcholine receptors (nAChRs) form a family of ACh-gated cation channels made up of different subtypes. They are widely distributed in peripheral and central nervous systems and are involved in complex cerebral processes as learning, memory, nociception, movement, etc. The possibility that subtype-selective ligands be used in the… (More)
A set of 1-(R-arylazo)-3,4,6,7,8,9-hexahydroquinolizines, bearing different substituents on the benzene ring, were prepared and tested for antimicrobial activity. These compounds exhibit only a very weak activity against gram-positive and gram-negative bacteria, but are fairly active against several Candida species and other yeast-like fungi.
A set of ten 2-phenyl-3-(quinolizidin-1-yl)-5-substituted indoles was prepared through the Fischer cyclization of lupinyl- and epi-lupinylphenylketone 4-substituted phenylhydrazones. Compounds were tested for antiaggregating activity on human platelets activated by adenosine diphosphate (ADP), collagen and adrenaline. At 2.5 x 10(-4) M concentration most… (More)
On the bases of personal experience the importance of endoscopic examination of the colon in the follow-up of patients who have been subjected to resection of the large intestine is emphasized. Fibercoloscopy permits direct observation of "high" surgical anastomoses, which are inaccessible for examination with rigid rectosigmoidoscope, and thus opens the… (More)
In the present study we compared different media for diagnosis of Candida albicans in the faeces to know the importance of the nonascosporic yeasts in alvine disorder. The first property was to find which field, among those known in literature, was more suitable in laboratory practice, for identification of the fungi. Among the cultural tested fields, the… (More)
A series of pharmacologically interesting 1- and 2-[omega-(4-arylpiperazin-1-yl)alkyl]-1,2,3-benzotriazoles, compounds 1-27, were synthesized (Scheme) and subjected to various biological studies to identify structure-activity relationships (SAR). The new compounds were found to exhibit good non-selective binding affinity towards the alpha1-adrenoreceptor… (More)
Thirteen [(aryl/heteroaryl-piperazinyl)alkyl]benzotriazoles were prepared as potential trazodone- and buspirone-like drugs. The synthesized compounds displayed from moderate to good affinity to the serotonin 5-HT1A receptor and only modest or poor affinity to the dopamine D2 receptor, similar to buspirone. The introduction of substituents on the… (More)