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The YEASTRACT (http://www.yeastract.com) information system is a tool for the analysis and prediction of transcription regulatory associations in Saccharomyces cerevisiae. Last updated in June 2013, this database contains over 200,000 regulatory associations between transcription factors (TFs) and target genes, including 326 DNA binding sites for 113 TFs.(More)
This paper presents a systematic literature review of the challenges, best practices, models, and tools in Distributed Software Development (DSD) Project Management. The objective is to collect and systematize reported knowledge in terms of what are the difficulties in managing DSD projects, what are the best practices to overcome these difficulties, and(More)
A brief survey of cortical development is presented, focusing on neuronal migration and its alterations. Corticogenesis is achieved through ordered temporospatial steps, via the formation of transient structures, and successive waves of cell proliferation and migration (followed by cell differentiation and maturation), and apoptotic cell death. The(More)
Several years ago software development has become critical to the global market. In the past decade, as a reflection of globalization, software companies began to distribute their development processes in different places, creating distributed software development (DSD). With the growing of Distributed Software Development, organizations have attempt to(More)
Opportunistic Candida species often have to cope with inhibitory concentrations of acetic acid, in the acidic environment of the vaginal mucosa. Given that the ability of these yeast species to tolerate stress induced by weak acids and antifungal drugs appears to be a key factor in their persistence and virulence, it is crucial to understand the underlying(More)
Infections caused by opportunistic fungal pathogens have reached concerning numbers due to the increase of the immunocrompromised human population and to the development of antifungal resistance. This resistance is often attributed to the action of multidrug efflux pumps, belonging to the ATP-binding cassette (ABC) superfamily and the major facilitator(More)
OBJECTIVES The ability of opportunistic pathogenic Candida species to persist and invade specific niches in the human host depends on their resistance to natural growth inhibitors and antifungal therapy. This work describes the role of the Candida glabrata drug:H(+) antiporter CgTpo3 (ORF CAGL0I10384g) in this context. METHODS Deletion and cloning of(More)
<b>Background:</b> Along the last decade, there has been a significant increase in the adoption of the approaches based on Distributed Software Development (DSD). This approach has brought several competitive advantages, as well as new challenges such as communication and information sharing. In this context, the ontologies can provide benefits such as the(More)