Catalina Matias Orozco

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Bisphosphonates are antiresorptive medications widely prescribed for treating osteoporosis. In placebo-controlled clinical trials they have been shown to significantly reduce the risk of osteoporotic fractures. However, reports of atypical femoral fractures and osteonecrosis of the jaw have emerged with long-term use, raising questions regarding their(More)
OBJECTIVE The Rheumatology Informatics System for Effectiveness (RISE) is a national electronic health record (EHR)-enabled registry. RISE passively collects data from EHRs of participating practices, provides advanced quality measurement and data analytic capacities, and fulfills national quality reporting requirements. Here we report the registry's(More)
OBJECTIVE We review available safety data for use of currently approved tumor necrosis factor (TNF) inhibitors during pregnancy and lactation and suggest guidelines for use of these agents among women of reproductive age. Method. Although regulatory agencies encourage the inclusion of pregnant women and those of child-bearing age in randomized controlled(More)
Rheumatoid arthritis (RA) is the most common form of inflammatory arthritis that affects the adult population. Early diagnosis and treatment are the cornerstones to prevent joint damage and avoid long-term costs and disability. This article reviews the limitations of the currently available tools for the evaluation of patients with early arthritis,(More)
The widespread use of electronic medical records (EMRs) is creating new opportunities to reimagine quality measurement and improvement in rheumatology. Previous quality measurement efforts have relied on analyses of administrative billing claims, such as the National Committee on Quality Assurance disease-modifying antirheumatic drug measure (1), or on(More)
In chronic kidney diseases, NTBI can occur even when total iron levels in serum are low and transferrin is not saturated. We postulated that elevated serum phosphate concentrations, present in CKD patients, might disrupt Fe(3+) loading into apo-transferrin by forming Fe(III)-phosphate species. We report that phosphate competes with apo-transferrin for(More)
Iron-containing ferritin has been used for light harvesting and as a photocatalyst. In this study, we test the hypothesis that changing the ironmineral core composition can alter the light harvesting and photocatalytic properties of ferritin, by co-depositing iron in the presence of halides or oxo-anions. This caused the anions to be incorporated into the(More)
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