Catalina B. de Di Risio

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Dear Editor: It is accepted that primary hepatocytes cultured on conventional tissue culture surfaces without extracellular matrix components are short-lived and display limited ability to replicate. They lose their metabolic capacity and end up irreversibly detached by 1 or 2 wk (Enat et al., 1984; Reid and Jefferson, 1984). As attempts to overcome these(More)
Hematopoietic progenitor colony assays were used to establish the effects of the vinca alkaloid vinorelbine (VRB) on murine bone marrow. The in vitro growth of colony-forming units–granulocyte/macrophage (CFU-GM), burst forming units–erythroid (BFU-E) and colony-forming units–mix (CFU-mix) was dose-dependently inhibited by VRB. The highest dose assayed(More)
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