Cassandra Bazile

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Many RNA binding proteins (RBPs) bind specific RNA sequence motifs, but only a small fraction (∼15%-40%) of RBP motif occurrences are occupied in vivo. To determine which contextual features discriminate between bound and unbound motifs, we performed an in vitro binding assay using 12,000 mouse RNA sequences with the RBPs MBNL1 and RBFOX2. Surprisingly, the(More)
1. Department of Biology, MIT, Cambridge MA 2. Program in Computational and Systems Biology, MIT, Cambridge MA 3. Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 4. Institute for Genomic Medicine, University of California at San Diego, La Jolla, CA 5. Bioinformatics and Systems Biology Graduate Program,(More)
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