Caspar A G Holleboom

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OBJECTIVE To assess the impact of elevated early follicular progesterone (P) levels in gonadotropin-releasing hormone (GnRH) antagonist cycles on clinical outcome using prospective data in combination with a systematic review and meta-analysis. DESIGN Nested study within a multicenter randomized controlled trial and a systematic review and meta-analysis.(More)
OBJECTIVE To evaluate the effect of ritodrine sustained release capsules for maintaining uterine quiescence after successful treatment of active preterm labour. DESIGN Multicentre placebo-controlled trial. SETTING Five teaching hospitals in the Netherlands. PARTICIPANTS Women (n = 95) at less than 35 weeks of gestation in whom active preterm labour(More)
OBJECTIVE To develop a ritodrine infusion scheme for preterm labour that avoids plasma levels above those needed for tocolysis, requires only one rate adjustment, and is easy to apply in practice. DESIGN Prospective study of tocolytic effect and plasma ritodrine concentrations during application of the infusion scheme. SETTING High risk labour ward. (More)
Immunotherapy of usual vulvar intraepithelial neoplasia (uVIN) is promising; however, many patients still fail to show clinical responses, which could be explained by an immune escape through alterations in human leukocyte antigen (HLA) expression. Therefore, we analyzed a cohort of patients with a primary (n = 43) and subsequent recurrent uVIN lesion (n =(More)
A 34-year-old patient with advanced primary squamocellular vaginal carcinoma was treated with external radiation (4000 cGy to the pelvis) and a line source Cesium application delivering 4000 cGy to the vaginal wall. During this treatment the patient developed a lesion on her back that proved to be a metastasis of a squamocellular cancer. The patient was(More)
OBJECTIVE To compare a new loading dose regimen for intravenous ritodrine administration in preterm labour with the conventional dose regimen. DESIGN Multicentre randomised trial using numbered opaque sealed envelopes. SETTING Five teaching hospitals in the Netherlands. PARTICIPANTS Women (n = 203) in preterm labour at less than 34 weeks of gestation.(More)
A loading-dose infusion scheme for intravenous ritodrine therapy was tested in twelve patients with preterm labour. We started with a rather high (386 micrograms/min) infusion rate, but the moment tocolysis was reached this infusion rate was reduced to a level needed to maintain the plasma concentration then found. Plasma samples of ritodrine were taken the(More)
Purpose The aim of the study was to compare the prophylactic effects of carbetocin with those of oxytocin for the prevention of uterine atony in patients undergoing elective caesarean section (CS) in the Netherlands. The primary endpoint was the need for additional uterotonic medication. Methods Each of the five participating Dutch hospitals treated 50–100(More)
PURPOSE The aim of the study was to compare the prophylactic effects of carbetocin with those of oxytocin for the prevention of uterine atony in patients undergoing elective caesarean section (CS) in the Netherlands. The primary endpoint was the need for additional uterotonic medication. METHODS Each of the five participating Dutch hospitals treated(More)
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