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Heme sensing in Bacillus thuringiensis: a supplementary HssRS-regulated heme resistance system.
Several Gram-positive pathogens scavenge host-derived heme to satisfy their nutritional iron requirement. However, heme is a toxic molecule capable of damaging the bacterial cell. Gram-positiveExpand
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Roles for Ena/VASP proteins in FMNL3-mediated filopodial assembly
ABSTRACT Filopodia are actin-dependent finger-like structures that protrude from the plasma membrane. Actin filament barbed-end-binding proteins localized to filopodial tips are key to filopodialExpand
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Tumor microtubes connect pancreatic cancer cells in an Arp2/3 complex-dependent manner
Actin-based tubular connections between cells have been observed in many cell types. Termed “tunneling nanotubes (TNTs),” “membrane nanotubes,” “tumor microtubes (TMTs),” or “cytonemes,” theseExpand
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Tumor microtubes connect pancreatic cancer cells in an Arp2/3 complex-dependent manner
Actin-based tubular connections between cells have been observed in many cell types. Termed “tunneling nanotubes (TNTs)”, “membrane nanotubes”, “tumor microtubes (TMTs)”, or “cytonemes”, theseExpand
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Directed evolution reveals the mechanism of HitRS signaling transduction in Bacillus anthracis
Two component systems (TCSs) are a primary mechanism of signal sensing and response in bacteria. Systematic characterization of an entire TCS could provide a mechanistic understanding of theseExpand
Lysine acetylation of cytoskeletal proteins: Emergence of an actin code.
Reversible lysine acetylation of nuclear proteins such as histones is a long-established important regulatory mechanism for chromatin remodeling and transcription. In the cytoplasm, acetylation of aExpand
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Directed evolution reveals the mechanism of HitRS signal transduction in Bacillus anthracis
Bacterial two component systems (TCSs) have been studied for decades; however, most work has focused on individual domains or proteins. Systematic characterization of an entire TCS could provide aExpand