Casey Costello

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Cultured cells from human premature aging syndromes show premature replicative senescence and as such might serve as models for genetic studies of cellular replicative senescence/aging. To date, no systematic study on chromosome-specific aneuploidy in premature aging syndromes has been carried out using molecular-cytogenetic techniques. We, therefore, have(More)
A disaccharide-chicken serum albumin conjugate vaccine against Candida albicans infections has been developed by reverse engineering a protective monoclonal antibody, C3.1. The binding site of C3.1 binds short oligosaccharides of β1,2-linked mannopyranose residues present in the fungal cell wall phosphomannan. By delineating the fine detail of the molecular(More)
Homopolysaccharides such as the protective β1,2-mannan present in the cell wall of Candida albicans have the capability to bind to antibody in numerous frame shifted modes. A protective monoclonal antibody C3.1 binds this antigen and exhibits a unique binding profile where di and trisaccharides are the most potent inhibitors, while the intrinsic affinities(More)
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