Caryl McAllister

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The roles of insulin resistance and beta-cell dysfunction in glucocorticoid-induced diabetes were determined in Wistar and Zucker (fa/fa) rats. All Wistar rats treated with 5 mg/kg per d of dexamethasone for 24 d exhibited increased beta-cell mass and basal and arginine-stimulated insulin secretion, indicating insulin resistance, but only 16% became(More)
Purified immunoglobulin G (IgG) from the serum of patients with insulin-dependent diabetes mellitus (IDDM) of recent onset inhibits high-Km uptake of 3-O-methyl-beta-D-glucose by rat pancreatic islets. To determine if the inhibition is the result of antibodies against GLUT-2, the high-Km glucose transporter of beta cells, we incubated IDDM sera with rat(More)
Potassium depletion often accompanies clinically significant magnesium depletion, and magnesium replacement is most frequently undertaken with magnesium sulfate. However, inorganic sulfate acts as a nonreabsorbable anion in the distal nephron, an effect that could potentially interfere with the correction of any associated potassium deficiency. We have(More)
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