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STUDY DESIGN Single-center prospective randomized controlled study. OBJECTIVE To evaluate the accuracy of robot-assisted (RO) implantation of lumbar/sacral pedicle screws in comparison with the freehand (FH) conventional technique. SUMMARY OF BACKGROUND DATA SpineAssist is a miniature robot for the implantation of thoracic, lumbar, and sacral pedicle(More)
OBJECTIVE This study assessed the feasibility and safety of percutaneous posterior pedicle screw fixation for instabilities of the thoracic and lumbar spine, using standard instruments designed for the open approach and fluoroscopy. METHODS All patients who underwent percutaneous posterior pedicle screw fixation of the thoracic and lumbar spine were(More)
STUDY DESIGN Retrospective, multicenter study of robotically-guided spinal implant insertions. Clinical acceptance of the implants was assessed by intraoperative radiograph, and when available, postoperative computed tomography (CT) scans were used to determine placement accuracy. OBJECTIVE To verify the clinical acceptance and accuracy of(More)
BACKGROUND Lumbar spinal stenosis is a degenerative disease of the elderly population. Although microsurgical decompression has shown good long-term results, percutaneous techniques could provide an alternative in the presence of significant comorbidities. METHOD Eighty-seven interspinous process decompression devices (In-space; Synthes, Umkirch, Germany)(More)
Saccular intracranial aneurysms are balloon-like dilations of the intracranial arterial wall; their hemorrhage commonly results in severe neurologic impairment and death. We report a second genome-wide association study with discovery and replication cohorts from Europe and Japan comprising 5,891 cases and 14,181 controls with approximately 832,000(More)
Alzheimer's disease (AD) is a neurodegenerative disorder primarily affecting regions of the brain responsible for higher cognitive functions. Immunization against β-amyloid (Aβ) in animal models of AD has been shown to be effective on the molecular level but also on the behavioral level. Recently, we reported naturally occurring autoantibodies against Aβ(More)
Growth patterns of skull base chordomas are related to important neurovascular structures. Local invasiveness results in "clinically malignant" behavior. A high rate of transient neurological deficits occurs following radical surgery. At our institution, the principle of radical removal is not followed at any price. This study compared the results of our(More)
BACKGROUND Most pilocytic astrocytomas (piloA) are benign growths (World Health Organization [WHO] grade 1) of the deep midline structures, the brainstem, and the cerebellum. To the authors' knowledge, the literature contains only scarce data regarding piloA in adults. METHODS Between 1995 and 2005, 44 patients (26 women and 18 men) underwent surgery for(More)
BACKGROUND AND STUDY AIM Spinal pyogenic infections occur frequently in today's neurosurgical routine. Conservative therapy often proves to be insufficient against an aggressive disease that affects patients who tend to be elderly and debilitated with complex comorbidity. Treatment, or lack of treatment, carries risks of persistent disability, sepsis, and(More)