Cortical inhibitory neurons contact each other to form a network of inhibitory synaptic connections. Our knowledge of the connectivity pattern underlying this inhibitory network is, however, still incomplete. Here we describe a simple and complementary interaction scheme between three large, molecularly distinct interneuron populations in mouse visual… (More)
K-Cl co-transporters are encoded by four homologous genes and may have roles in transepithelial transport and in the regulation of cell volume and cytoplasmic chloride. KCC3, an isoform mutated in the human Anderman syndrome, is expressed in brain, epithelia and other tissues. To investigate the physiological functions of KCC3, we disrupted its gene in… (More)
A high intracellular chloride concentration in immature neurons leads to a depolarizing action of GABA that is thought to shape the developing neuronal network. We show that GABA-triggered depolarization and Ca2+ transients were attenuated in mice deficient for the Na-K-2Cl cotransporter NKCC1. Correlated Ca2+ transients and giant depolarizing potentials… (More)
Recent studies on vasoactive intestinal peptide-expressing inhibitory neurons in the barrel and auditory cortices of the mouse brain have shown that they form a disinhibitory circuitry that affects the excitability of pyramidal neurons.
Synaptic inhibition in the olfactory bulb (OB), the first relay station of olfactory information, is believed to be important for odour discrimination. We interfered with GABAergic inhibition of mitral and tufted cells (M/T cells), the principal neurons of the OB, by disrupting their potassium-chloride cotransporter 2 (Kcc2). Roughly, 70% of mice died… (More)
Copyright c by the paper's authors. Copying permitted for private and academic purposes. dass zusätzliche Konstrukte wie main-Funktionen oder Klassen eingeführt werden müssen. sie auch in UML-Klassendiagrammen [RJB04] verwendet werden. Dabei steht + für public, # für protected,-für private und ~ für package. Die Methode initializer wird bei der… (More)