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Since the introduction of 3-D rotational X-ray imaging, protocols for 3-D rotational coronary artery imaging have become widely available in routine clinical practice. Intra-procedural cardiac imaging in a computed tomography (CT)-like fashion has been particularly compelling due to the reduction of clinical overhead and ability to characterize anatomy at(More)
The purpose of this study was to determine the shear compliance of human crystalline lenses as a function of age and frequency. Dynamic mechanical analysis was performed on 39 human lenses, ranging in age from 18 to 90 years, within the frequency range of 0.001-30 Hz. The lenses were stored at -70 degrees C before being measured. The influence of freezing(More)
Dynamic programming is a classical programming technique, applicable in a wide variety of domains such as stochastic systems analysis , operations research, combinatorics of discrete structures, flow problems , parsing of ambiguous languages, and biosequence analysis. Little methodology has hitherto been available to guide the design of such algorithms. The(More)
We present our recent progress in filled pause (FP) modeling for a highly spontaneous medical transcription task. Our studies confirm that FP modeling is an important topic for spontaneous speech applications, which must be explicitly addressed in acoustic, lexical , and language modeling. We provide a framework for data-driven lexical modeling of FP(More)
PURPOSE To investigate intraocular concentrations and pharmacokinetics of bevacizumab after a single intravitreal injection in humans. DESIGN Prospective, noncomparative, interventional case series. METHODS We included 30 nonvitrectomized eyes of 30 patients (age range, 43 to 93 years) diagnosed with clinically significant cataract and concurrent(More)
Segmentation of medical images can be achieved with the help of model-based algorithms. Reliable boundary detection is a crucial component to obtain robust and accurate segmentation results and to enable full automation. This is especially important if the anatomy being segmented is too variable to initialize a mean shape model such that all surface regions(More)
The determination of temporal and spatial correlations in neuronal activity is one of the most important neurophysiological tools to gain insight into the mechanisms of information processing in the brain. Its interpretation is complicated by the difficulty of disambiguating the effects of architecture, single-neuron properties, and network dynamics. We(More)
OBJECTIVE To determine the prevalence and visual significance of cystoid macular edema (CME) in eyes with subfoveal neovascular age-related macular degeneration using optical coherence tomography (OCT). MATERIALS AND METHODS The medical records of 61 consecutive patients initially seen with nondisciform subfoveal neovascular age-related macular(More)
BACKGROUND Photodynamic therapy (PDT) is a well established clinical treatment for age-related macular degeneration (AMD), and comprises intravenous injection of verteporfin and subsequent application of a non-thermal laser beam to the area of AMD to induce selective vascular occlusion. Since there is evidence that PDT may cause outer blood-retinal barrier(More)