Carrie E Sanders

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Interest in nonimmunologic factors affecting longterm graft survival has focused on adequacy of nephron dosing. Body surface are (BSA) is a reliable surrogate for nephron mass. In a retrospective study of 378 primary recipients of paired kidneys from 189 cadaveric donors, we assessed the impact of matching donor and recipient BSA on outcome over 7 years.(More)
INTRODUCTION The use of extended criteria donors (ECDs) could minimize shortage of suitable donor livers for transplantation. In 3 years, the aggressive use of ECD livers has reduced the wait list at our center from 257 to 30 patients with a median wait time of 18 days without using living donors. This study compares the graft/patient survival from standard(More)
The damaging effects of essential hypertension and the central role of the kidney in its pathogenesis have long been recognized. Essential hypertension is the second leading cause of end-stage renal disease in the United States, with its prevalence increasing dramatically over the last decade. Similarly, the role of the transplanted kidney in the(More)
BACKGROUND Graft thrombosis is the most common cause of early graft loss after pancreas transplantation. Early reexploration may permit salvage or timely removal of the thrombosed graft. METHODS This was a retrospective review of 345 pancreas transplants performed at a single center between January 2003 and December 2009. Early reexploration was defined(More)
In patients with primary cadaveric renal transplants and stable allograft function, we assessed the impact of tapering or discontinuing cyclosporine A (CsA) for financial reasons. Forty-two patients whose CsA was discontinued ("no-dose") and 29 patients whose CsA was tapered to 100 to 150 mg/d ("low-dose"; mean, 1.7 mg/kg/d) were examined. Results were(More)
Financial circumstances force some stable renal transplant recipients to discontinue cyclosporine (CsA). Previous results from our center document a subgroup of these patients at increased risk for acute rejection and allograft loss, namely, those of African ancestry. After 1988, such disadvantaged recipients have been able to receive CsA at no charge(More)
Meticulous preparation of the allograft on the back bench is one of the cornerstones of technically successful whole-organ pancreas transplantation. With evolving surgical approaches for organ retrieval and implantation, it has become routine to procure the pancreas in conjunction with other abdominal organs without sacrificing vasculature or graft quality(More)
Histological examination of renal allograft tissue has become the accepted standard in diagnosing acute rejection. We present three cases of allograft dysfunction in which the histological findings and clinical course differed. Reliance on histology alone in therapeutic decision making might have resulted in inappropriate clinical interventions. In renal(More)
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