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The purpose of this study was to investigate the influence of continuous perfusion and mechanical stimulation on bone marrow stromal cells seeded on a collagen meniscus implant. Bone marrow aspirates from 6 donors were amplified in vitro. 106 human BMSC were distributed on a collagen meniscus implant. Scaffolds were cultured under static conditions(More)
BACKGROUND Acrolein is a reactive aldehyde present in high amounts in coal, wood, paper, and tobacco smoke. It is also generated endogenously by lipid peroxidation and the oxidation of amino acids by myeloperoxidase. In animals, acrolein exposure is associated with the suppression of circulating progenitor cells and increases in thrombosis and(More)
The microfracture technique has become an established method for the treatment of chondral lesions in the knee. The aim of this study was to determine its usefulness in the treatment of osteochondral (OCL) and degenerative chondral lesions (DCL) of the talus. In a prospective study, 32 patients with an osteochondral lesion (22 patients) or degenerative(More)
Prostheses with single radius (SR) design were supposed to be as good as the physiological kinematic and stability of the knee. This in-vitro biomechanical study compared SR to a multiple radius (MR) design on the one hand and seven left human knee specimens were used. The SR and MR knee prosthesis where implanted with a navigation system. We measured(More)
The aim of the present study was to analyse and compare the clinical and radiological results after open posterior bone block procedure at long- (LT) and short-term (ST) follow-up. The hypothesis was that placement of a bone block at the posterior glenoid rim in a technique of extending the glenoid surface will create permanent joint stability even in cases(More)
OBJECTIVES Previous studies have shown that residential proximity to a roadway is associated with increased cardiovascular disease risk. Yet, the nature of this association remains unclear, and its effect on individual cardiovascular disease risk factors has not been assessed. The objective of this study was to determine whether residential proximity to(More)
Die Technik der Mikrofrakturierung hat sich in der Therapie von Knorpelläsionen am Talus etabliert. Die Indikation zur arthroskopischen Mikrofrakturierung besteht bei symptomatischer chondraler oder osteochondraler Läsion ab Stadium II, wenn der Knorpel bei der Begutachtung mit dem Tasthaken deutlich erweicht oder aufgebrochen ist. Bei ausgedehnten(More)
Zur operativen Therapie einer patellaren Instabilität oder degenerativer patellofemoraler Veränderungen werden im klinischen Alltag häufig knöcherne Eingriffe mit Transfers der Tuberositas tibiae eingesetzt. Dieser Eingriff hat Auswirkungen auf die retropatellare Druckbelastung und auf die Kinematik der Patella. Je nachdem in welche Richtung dieser Transfer(More)
Die autologe Knorpelzelltransplantation (ACT) wird zur Therapie von Knorpelläsionen im oberen Sprunggelenk im Gegensatz zur Anwendung am Knie noch relativ selten durchgeführt. Mittlerweile wird in aller Regel eine matrixassoziierte Knorpelzelltransplantation (MACT) verwendet. Dabei werden die Zellen auf Biomaterialen aufgebracht, um ein(More)
This cadaveric study compares the biomechanical properties of femoral graft fixation in ACL reconstruction of either quadriceps or hamstring tendon grafts with four different interference screws. The hypothesis was that quadriceps tendon grafts provide at least equal results concerning gap formation during cyclic loading and ultimate failure load compared(More)