Carrie B Chapman

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The classical Starling hypothesis, based on studies of isolated heart preparations, assigns the dominant role in cardiac control to the functional relation between end-diastolic fiber length and stroke work; it acknowledges the influence of autonomic factors, but considers them less fundamental than the intrinsic myocardial factor (1, 2). At the other(More)
BACKGROUND Heart failure in patients with preserved left ventricular systolic function (HFpEF) is a prevalent disease characterized by exercise intolerance with poorly understood pathophysiology. We hypothesized that recruitable contractility is impaired in HFpEF, accounting for the appearance of symptoms with exertion. METHODS AND RESULTS(More)
A biplane cinefluorographic technic for measuring ventricular volume is described and its accuracy and limitations are assessed. Although rather complicated and time-consuming at present, the method permits construction of volume curves and estimation of stroke volume of the left ventricle for several successive contractions in the intact animal or man.(More)