Regulatory T (T(reg)) cells expressing forkhead box P3 (Foxp3) arise during thymic selection among thymocytes with modestly self-reactive T cell receptors. In vitro studies suggest Foxp3 can also be induced among peripheral CD4(+) T cells in a cytokine dependent manner. T(reg) cells of thymic or peripheral origin may serve different functions in vivo, but… (More)
In a pedigree of C57BL/6J mice homozygous for germline mutations induced by the mutagen N-ethyl-N-nitrosourea (ENU), numerous animals died under specific pathogen-free (SPF) conditions between 6 and 7 months of age. Death was caused by nephritic syndrome, which progressed to renal failure associated with focal segmental glomerulosclerosis. To identify the… (More)
We present a compendium of N-ethyl-N-nitrosourea (ENU)-induced mouse mutations, identified in our laboratory over a period of 10 years either on the basis of phenotype or whole genome and/or whole exome sequencing, and archived in the Mutagenetix database. Our purpose is threefold: 1) to formally describe many point mutations, including those that were not… (More)
B lymphopoiesis begins in the fetal liver, switching after birth to the bone marrow, where it persists for life. The unique developmental outcomes of each phase are well documented, yet their molecular requirements are not. Here we describe two allelic X-linked mutations in mice that caused cell-intrinsic arrest of adult B lymphopoiesis. Mutant fetal liver… (More)
V a p i n g a n d H e a l t h W h a t D o W e K n o w a b o u t E-C i g a r e t t e s ? Advertisements for e-cigarettes claim they help smokers curb their habit while inhaling only " harmless water vapor, " but few tests have been conducted to confirm these claims.
DynaTable is an extension for the MediaWiki software that provides support for structured data. While tables and lists are popular features in many wikis, they are currently unsupported as first-class entities. As a consequence, creating and editing tables is a manual, error-prone task. DynaTable allows wiki editors to create tables that can be displayed on… (More)