Carolyn W. Harley

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The effects of the NMDA blockers, AP5 and MK-801, were assessed in two spatial tests. AP5 (10 micrograms in 2 microliters ICV, N = 6), or MK-801 (0.07 mg/kg IP, N = 6), significantly increased open-field activity in male Long-Evans rats in two 3-min tests (Days 1 and 2) compared to control groups receiving equal volume saline injections (N = 12). In the(More)
Cue control in spatial learning was investigated in a plus maze and a Morris maze. Rats transported in opaque containers with prior rotation to a plus maze, but not a Morris maze, could not find a goal defined by external cues. Rats transported in clear containers without rotation found the goal in both mazes. In the Morris maze, goal location was readily(More)
Rats learned to find the baited corner of a box surrounded by a curtain, regardless of whether they had a fixed or random point of entry (POE) through the curtain. On probe trials, rats used an internal direction sense carried from outside the curtain to solve the problem, and only used the visual cue inside the curtain if disoriented and denied access to a(More)
Path integration provides guidance based on cues generated by a point of reference (usually start location) and subsequent self-movement. This well-established mechanism suggests start location may have special significance and might provide a useful window into memory in rats. In an earlier study rats did not learn to return to a start location in a(More)
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