Carolyn McChesney

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We evaluated ventricular-brain ratio with computed tomographic scanning in a sample of 108 DSM-III-diagnosed schizophrenic patients and 75 healthy normal volunteers. Significant differences were noted between the patients and controls, but our large sample size also permitted us to determine that the statistically significant difference was contributed(More)
The frequency of generalized anxiety disorder was higher among first-degree relatives of probands with generalized anxiety (N = 20) than among the relatives of control subjects (N = 20), but it was not higher among relatives of probands with panic disorder (N = 40) or agoraphobia (N = 40). Also, the frequency of panic disorder was higher among relatives of(More)
A family study of patients with agoraphobia (n = 40), panic disorder (n = 40), and nonanxious controls (n = 20) showed that the morbidity risk for panic disorder was increased among the relatives of agoraphobics (8.3%) and the relatives of patients with panic disorder (17.3%). The morbidity risk for agoraphobia was also increased among the relatives of(More)
A stratified sample of 996 nursing school graduates from 1963 to 1984 was surveyed by mail regarding menstrual cycle characteristics. The 730 respondents reported an 87% overall lifetime prevalence of premenstrual symptoms. When the symptoms were categorized according to severity, only 3.2% of the respondents reported severe symptoms. Symptomatic women used(More)
We studied 45 depressed patients and 20 healthy controls in order to determine if tritiated imipramine binding distinguished among subtypes of primary major depressive disorder. Mean (+/- standard deviation) values for maximal concentration of tritiated imipramine binding sites on platelet membranes were significantly lower in patients with bipolar and(More)
In response to the challenge of providing care for cancer patients closer to home, community chemotherapy outreach programs are being developed as part of regional cancer care organizations. The purpose of this qualitative study was to gain an understanding of cancer patients' experiences of receiving chemotherapy at community chemotherapy clinics. In(More)
Acute injection of glutamate into frontal neocortex of naive rats produced a subsequent deficit in escape performance behavior that was similar to that produced by exposure to uncontrollable shock. The behavioral deficit was dose-related. The behavioral deficit was similar in time-course to that produced by 15 min (but not 40 min) of exposure to learned(More)