Carolyn K. Good

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Animal models provide a unique opportunity to study the biology of the disease process, and to test hypotheses linking environmental factors in the etiology and prevention of colon cancer. The concept of cancer prevention is to retard, regress or eliminate precancerous lesions. To actuate this concept, it is important to identify and enumerate preneoplastic(More)
OBJECTIVE Prospective studies have suggested that substituting whole grain for refined grain products may lower the risk of overweight and obesity. Breakfast cereal intake is a major source of whole and refined grains and has also been associated with having a lower BMI. The aim of this study was to prospectively assess the association between whole and(More)
OBJECTIVE To examine the relationship between whole grain consumption and body mass index (BMI) in a sample of American adult women. METHODS Dietary intake data from the National Health and Nutrition Examination Survey 1999-2000 were linked to the USDA Pyramid Servings Database. Women 19 years of age and older (n = 2,092) were classified into groups based(More)
Flaxseed contains several dietary components that have been linked to low breast cancer risk; i.e., n-3 polyunsaturated fatty acids (PUFAs), lignans and fiber, but it also contains detectable levels of cadmium, a heavy metal that activates the estrogen receptor (ER). Since estrogenic exposures early in life modify susceptibility to develop breast cancer, we(More)
The relationship between extracellular proteinase and the virulence for mice in Candida albicans was studied by using a set of three isolates. The set included a proteinase-producing parent (C9), a proteinase-deficient mutant derived from C9 by nitrous acid treatment (C9M1), and a spontaneous revertant (C9M1M) obtained by mouse passage of C9M1. The(More)
BACKGROUND Conflicting results from vitamin E intervention studies suggest supplemental vitamin E malabsorption. OBJECTIVE We compared vitamin E bioavailability from a supplement with that from a fortified breakfast cereal. DESIGN Vitamin E bioavailability was evaluated by using deuterium-labeled all-rac-alpha-tocopherol in three 4-d trials (2 wk(More)
The main objective of the present study was to investigate the amenability of preneoplastic lesions at different developmental stages to the growth-regulatory effects of two types of dietary lipids. F344 male rats were given three injections of azoxymethane (15 mg/kg) and fed a low-fat corn oil diet for 12 weeks to allow preneoplastic lesions or aberrant(More)
Insulin is associated with augmented colon carcinogenesis in vivo, but the mechanism(s) of growth promotion is not known. This study investigates the expression profile of a key component of the insulin signaling pathway, the insulin receptor (IR), in colonic tumors in comparison to normal colonic mucosa and the effects of dietary lipids. Male F344 rats(More)
In this three-phase study we first compared the availability of fourteen Fe forms in a wheat-based ready-to-eat breakfast cereal using an in vitro digestion/human colonic adenocarcinoma (CaCo-2) cell model. We then investigated the effect of milk and/or coffee on those fortified cereals found in phase 1 to show promising increases in Fe availability. The Fe(More)
Our objective was to investigate the ability of preneoplastic colonic lesions at different stages of development to respond to the growth-retarding effects of energy restriction (ER). Male Fischer 344 rats were given three injections of azoxymethane (15 mg/kg s.c.) and fed a high-fat corn oil diet for 16 weeks. This duration allowed aberrant crypt foci(More)