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Regions of the short arm of chromosome 8 are deleted frequently in a range of solid tumors, indicating that tumor suppressor genes reside at these loci. In this study, we have examined the properties of the Wnt signaling antagonist secreted frizzled-related protein (sFRP) 1 as a candidate for this role at c8p11.2. An initial survey of 10 colorectal tumors,(More)
Latent transforming growth factor-beta-binding proteins (LTBPs) are extracellular matrix (ECM) glycoproteins that play a major role in the storage of latent TGF beta in the ECM and regulate its availability. Here we show that fibronectin is critical for the incorporation of LTBP1 and transforming growth factor-beta (TGF beta) into the ECM of osteoblasts and(More)
The recent birth of a camel-llama hybrid, after numerous failed attempts, has prompted an investigation into the glycosylation of apposing fetal and maternal tissues of pregnant camels and alpacas. This study was undertaken to determine whether interspecies differences in glycans are factors that may account in part for the difficulty in producing a viable(More)
It has been previously proposed that there is a primary microvascular abnormality in patients with systemic sclerosis. In this study using conventional light and electron microscopy, immunohistochemistry, and labelled adenosine uptake techniques, changes in the dermal microvasculature have been related to the various clinical stages of skin disease in(More)
The nucleotide sequence of members of an alpha-repeat subfamily shared by human chromosomes 14 and 22 is presented. This subfamily is organized into a higher-order repeat unit composed of a tandem repetition of an ordered array of four related but distinct 340-bp repeat dimers. An analogous situation has been described for a related but distinct subfamily(More)
Three methods were used to prepare microvillus membrane vesicles from each of six human placentas. Two of these incorporated an agitation stage to preferentially remove microvilli and either Ca2+ (Method 1) or Mg2+ (Method 2) aggregation of non-microvillus membrane. The third method involved homogenisation of the tissue followed by Mg2+ aggregation of(More)
Specimens of mid-term (horse), near-term (pig, cow, sheep, mink) and term (human) placentae and associated tissues have been examined with a panel of 15 biotinylated lectins combined with an avidin-peroxidase revealing system. The aim of this study has been to analyse the expression of glycans at the materno-fetal interface in order to establish whether the(More)
Placentae of 22 one-humped camel concepti with crown-rump lengths (CRL) ranging from 2.5 to 26 cm were studied. The placentae were processed for light, transmission and scanning electron microscopy of exposed surfaces and microvascular corrosion casts. In very early stages of pregnancy (2.5-4.5 cm CRL) three froms of fetomaternal interrelationship are(More)
Within the last 25 yr, the study of glycans, their structures, and their drstribution in tissues has emerged from relative obscurity to become a major theme of molecular and cellular biology: "glycobiology" (1). Glycans are major components of cellular surfaces (2,3), extracellular matrices (4,5), and secretions (6), and play important roles in cell-cell(More)
Comparison has been made between glycans at the fetomaternal interface of two Tayassu species (New World peccaries or wild pigs) and those of swine (true pigs) and dromedary, which have similar epitheliochorial placentae. Plastic sections of near-term fetomaternal interface from Tayassu tajacu (120 days gestation) and Tayassu pecari (140 days gestation)(More)