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Next-generation sequencing does not yield fully unbiased estimates for read abundance, which may impact on the conclusions that can be drawn from sequencing data. The ligation step in RNA sequencing library generation is a known source of bias, motivating developments in enzyme technology and library construction protocols. We present the first comparison(More)
  • William J. Faller, Thomas J. Jackson, John RP Knight, Rachel A. Ridgway, Thomas Jamieson, Saadia A. Karim +17 others
  • 2015
Inactivation of APC is a strongly predisposing event in the development of colorectal cancer, prompting the search for vulnerabilities specific to cells that have lost APC function. Signalling through the mTOR pathway is known to be required for epithelial cell proliferation and tumour growth, and the current paradigm suggests that a critical function of(More)
  • Christopher M. Hogan, Thomas H. Thatcher, Ramil E. Sapinoro, Michael N. Gurell, Heather E. Ferguson, Stephen J. Pollock +3 others
  • 2011
Acute and chronic lung inflammation is associated with numerous important disease pathologies including asthma, chronic obstructive pulmonary disease and silicosis. Lung fibroblasts are a novel and important target of anti-inflammatory therapy, as they orchestrate, respond to, and amplify inflammatory cascades and are the key cell in the pathogenesis of(More)
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