Carolyn H Glass

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Given the increasing numbers of patients requiring long-term hemodialysis, there is an inevitably increasing population of patients with occluded central venous inflow (subclavian, innominate, and caval) despite access or access possibilities in the arm. In an effort to avoid sternotomy, we have attempted to treat these patients with a substernally tunneled(More)
The ecotropic virus integration site 1 (EVI1) transcription factor is associated with human myeloid malignancy of poor prognosis and is overexpressed in 8-10% of adult AML and strikingly up to 27% of pediatric MLL-rearranged leukemias. For the first time, we report comprehensive genomewide EVI1 binding and whole transcriptome gene deregulation in leukemic(More)
The EVI1 oncogene at human chr 3q26 is rearranged and/or overexpressed in a subset of acute myeloid leukemias and myelodysplasias. The EVI1 protein is a 135 kDa transcriptional regulator with DNA-binding zinc finger domains. Here we provide a critical review of the current state of research into the molecular mechanisms by which this gene plays a role in(More)
Recent advances in the treatment of venous insufficiency have led to an increased utilization of venous ultrasonography by practitioners. Knowing the fundamentals of anatomy and physiology are essential to be successful. This article reviews the common uses of ultrasonagraphy for the examination of the lower extremity venous system.
BACKGROUND Endoscopic saphenous vein harvest (EVH) has been shown to lower wound infection rates and cost compared with conventional harvest, although long-term patency data are lacking. A small series of studies has recently suggested that patency is inferior to conventionally harvested vein technique, and we thus sought to explore this question by(More)
BACKGROUND The incidence of stage 5 chronic kidney disease requiring immediate hemodialysis treatment continues to rise with an increasing number of patients with an unsuitable cephalic vein or failed radio- and brachiocephalic fistulae. In these patients the basilic vein is our next autologous choice. We have previously investigated our preliminary(More)
BACKGROUND The 0+5 integrated vascular residency training pathway was established in 2006 to allow for trainee-focused training culminating in vascular surgery certification only. An early concern was whether enough medical students could be recruited directly into a vascular internship without the exposure that a general surgery residency provides. We(More)
Pressure support ventilation decreases the work of breathing by providing the patient with positive airway pressure during the inspiratory phase. The use of this type of ventilatory support is likely to increase over the next few years for patients, especially during the weaning period. By understanding how pressure support ventilation works and what(More)