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  • C M Bate
  • 1976
Maps of the thoracic and abdominal neuroblasts have been prepared by reconstruction from serial sections of timed Locusta migratoria embryos. The maps are bilaterally symmetrical, periodic and consistent for embryos of the same age, with a fundamental arrangement of 7 rows of 4-10 cells plus 1 median neuroblast per segment. A map of 60 + 1 cells is repeated(More)
The intersegmental connectives in the locust central nervous system are initiated by the axons of early differentiating neuron trios. Using a combination of electron microscopy and fluorescent dye injection we have shown that the axons of these cells grow out anteriorly and posteriorly in each segment along a basement membrane, and link together at the(More)
BACKGROUND/AIMS Dilatation combined with subsequent pharmacological control of gastroesophageal reflux represents a logical but poorly documented approach to the management of benign esophageal stricture. This large trial (366 patients) aimed to assess whether omeprazole as the most effective available medication for gastroesophageal reflux disease prevents(More)
By discrete manipulation of the endocrine cues that control insect metamorphosis, it has been possible to examine the mechanisms governing the growth of neural processes during development. During the transition from larva to pupa in the hawkmoth, Manduca sexta, identified sensory neurons reorganize their central projections to evoke a new behavior--the(More)
Geographical variations in the prevalence of hepatitis B infection were found in association with an increased opportunity of exposure to this virus in patients with homozygous beta-thalassemia in Cyprus, Greece, Sardinia and the United Kingdom. No association was found between the Gm phenotype of the individuals investigated and susceptibility to hepatitis(More)
BACKGROUND Previous studies have demonstrated greater efficacy for omeprazole compared with cimetidine in patients with endoscopically verified oesophagitis, but excluded the substantial group of gastro-oesophageal reflux disease (GERD) patients with reflux symptoms but without endoscopic abnormality. This prospective, randomized, double-blind study(More)
BACKGROUND There is documentation of the long-term use of omeprazole 10 mg o.d. in patients with reflux oesophagitis but not in the large number of gastrooesophageal reflux disease (GERD) patients without oesophagitis. There is also a paucity of data on the long-term use of cimetidine in GERD patients. METHODS One hundred and fifty-six patients (100 male)(More)
This study was designed to establish whether 40 mg omeprazole once daily exhibits sufficient additional efficacy over that of 20 mg omeprazole once daily in patients with symptomatic reflux oesophagitis requiring more than an initial 4-week course of 20 mg omeprazole once daily (o.m.) to warrant routine use of the higher dose. Three hundred and thirteen(More)
BACKGROUND As many as 50% of patients with reflux symptoms have no endoscopic evidence of oesophagitis. This multicentre study was designed to assess symptom relief after omeprazole 20 mg once daily in patients with symptoms typical of gastro-oesophageal reflux disease but without endoscopic evidence of oesophagitis. METHODS Patients (n = 209) were(More)